“…Genomic regions of HIV-1rmt clones derived from HIV-1 NL4-3, SIVmac MA239, and SIVgsn 166 (SIV isolated from the greater spot-nosed monkey) are depicted by white, blue, and orange areas, respectively. Generation and characterization of HIV-1 NL4-3 ( Adachi et al, 1986 ), SIVmac MA239 ( Shibata et al, 1991 ), CXCR4-tropic HIV-1rmt designated MN4/LSDQgtu ( Nomaguchi et al, 2013b ; Nomaguchi et al, 2017 ), CCR5-tropic HIV-1rmt designated MN5/LSDQgtu ( Nomaguchi et al, 2013b ; Nomaguchi et al, 2017 ), and CCR5-tropic HIV-1rmt designated gtu + A4CI1 ( Doi et al, 2017 ) have been fully described previously. MN4/LSDQgtu and MN5/LSDQgtu carry growth-enhancing mutations in Gag-capsid, Pol-integrase, and Env regions as previously described ( Nomaguchi et al, 2013a , b ).…”