Generation and Gender Differences in the Components Contributing to the Diagnosis of the Metabolic Syndrome According to the Japanese Criteria

Kobayashi, Junji; Nishimura, Kouji; Matoba, Munetoshi; Maekawa, Nobumasa; Mabuchi, Hiroshi

doi:10.1253/circj.71.1734

Cited by 33 publications

(20 citation statements)

References 23 publications

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“…In the comparison between the two waist-circumference groups (≥ 85 cm and < 85 cm), the level of BMI, body fat, waist circumference, blood pressure, triglyceride, and fasting blood glucose were higher and the level of HDL cholesterol was lower in those with larger waist circumference than in their smaller-waist counterparts, which is in agreement with previous studies (Mori et al 2006;Kobayashi et al 2007). In the current version of Japanese MetS criteria for men, a waist circumference of ≥ 85 cm has been identified as a priority, but the disregard for those with a smaller waist circumference is never addressed in our daily practice.…”

Section: Discussionsupporting

confidence: 92%

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

Inoue

Nakao

Nomura

et al. 2011

Tohoku J. Exp. Med.

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A focus exclusively on waist circumference, the main component used in the diagnosis of metabolic syndrome (MetS), may lead to ignoring non-obese individuals with other MetS components, including high levels of blood pressure, fasting blood glucose, and triglycerides and low levels of high-density lipoprotein. This study investigated lifestyles and eating behaviors among non-obese individuals with components of MetS. Of the 918 Japanese male workers, 151 subjects (16.4%) had a waist circumference < 85 cm with more than one MetS component. This non-obese high-risk group for MetS gained weight in adulthood, consume alcohol, and engage in less leisure-time physical activity compared to 317 subjects (34.5%) with a waist circumference < 85 cm and without MetS components (p < 0.05). The remaining 450 subjects (49%) were obese with a waist circumference ≥ 85, including 93 men with MetS. A lack of leisure-time physical activity was associated with the non-obese high-risk group for MetS [odds ratio 1.59, 95% confidence interval 1.02 -2.49] compared to the 317 non-obese men without MetS (reference group). Such a difference in physical activity was not found between the 450 obese subjects and the reference group. Instead, eating behaviors, such as eating rapidly, preference for fatty foods, and eating out for dinner, were significantly associated with MetS. Thus, men with smaller waist circumferences and any MetS component should be carefully monitored for physical activity to prevent further development of MetS, while men with larger waist circumferences including MetS need to be monitored for unfavorable eating behaviors.

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Section: Discussionsupporting

confidence: 92%

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

Inoue

Nakao

Nomura

et al. 2011

Tohoku J. Exp. Med.

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“…[28][29][30][31] Here we showed that aging is associated with the reduction of activity of only one of the various antioxidant enzymes. In addition, we investigated the association of aging with the tolerance of macrophages against oxLDL.…”

Section: Mnsod Activity and Macrophage Apoptosismentioning

confidence: 88%

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

Fujimoto

Kobayashi

Ohno

2010

Circ J

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“…In humans, insulin sensitivity normally decreases with aging, and the prevalence of MS or type 2 diabetes, both of which share the common pathogenesis of insulin resistance, increases with advancing age 31,32) . Individuals with MS are at a greater risk for various illnesses, including cardiovascular disease (CVD), which increases morbidity and mortality among the elderly.…”

Section: Human Data On the Adipose Tissue Phenotype In Centenariansmentioning

confidence: 99%

Adipokines and Aging

Arai

Takayama

Abe

et al. 2011

JAT

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Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystrophic syndromes and Hutchinson-Gilford progeria syndrome, both of which are caused by mutations in the LMNA gene, loss of adipose tissue is associated with adipokine dysregulation, insulin resistance, and atherosclerosis, suggesting a critical role of adipose tissue function in controlling whole body energy metabolism, age-related pathologies, and longevity. Centenarians, a model of healthy aging and longevity, are reported to exhibit preserved insulin sensitivity as well as favorable adipokine profiles, particularly high levels of circulating adiponectin. Furthermore, adipose tissue dysfunction indicated by dysregulation of leptin, tumor necrosis factor-, and adiponectin is associated with poor prognosis in centenarians. In contrast to results obtained for obesity, adipokine dysregulation in centenarians is associated with very low leptin levels, suggesting that age-related lipoatrophy is the major factor for adipose tissue dysfunction at an advanced age. These observations suggest that adipose tissue excess as well as its aging is implicated in the regulation of adipokines, insulin sensitivity, and lifespan in humans.J Atheroscler Thromb, 2011; 18:545-550.

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Generation and Gender Differences in the Components Contributing to the Diagnosis of the Metabolic Syndrome According to the Japanese Criteria

Cited by 33 publications

References 23 publications

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

Adipokines and Aging

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