Generation and validation of a universal perinatal database and biospecimen repository: PeriBank

Antony, Kathleen M.; Hemarajata, Peera; Chen, J.; Morris, Jocelyn; Kyrillidou, Martha; Masalas, D.; Gedminas, M.; Brown, Allen C.; Versalovic, James; Aagaard, Kjersti M.

doi:10.1038/jp.2016.130

Cited by 39 publications

(42 citation statements)

References 41 publications

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“…A detailed description of PeriBank has been published previously. 15 At the time of admission, gravidae were enrolled by trained PeriBank research personnel after written informed consent was obtained. Up to 4,900 variables of clinical data were sought from the electronic medical record, prenatal records, and by in-person interview.…”

Section: Methodsmentioning

confidence: 99%

“…as previously published. 15 Clinical data that were extracted for this study comprise the patient history (including prior and familial occurrence of preeclampsia, smoking status, nicotine and substance use, familial obstetrical history, and prenatal care clinics and providers), socioeconomic status (education, income, immigration status) and residential and workplace data (each trimester of pregnancy residence and work place five-digit zip code). Not all 4,900 potential PeriBank variables were employed in this analysis.…”

Section: Methodsmentioning

confidence: 99%

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Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Tolcher

Chu

Hollier

et al. 2017

American Journal of Obstetrics and Gynecology

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BACKGROUND The U.S. Preventive Services Task Force (USPSTF) recommends low-dose aspirin for the prevention of preeclampsia among women at high risk for primary occurrence or recurrence of disease. Recommendations for the use of aspirin for preeclampsia prevention were issued by the USPSTF in September 2014. OBJECTIVES To evaluate the incidence of recurrent preeclampsia in our cohort before and after the USPSTF recommendation for aspirin for preeclampsia prevention. STUDY DESIGN This is a retrospective cohort study designed to evaluate rates of recurrent preeclampsia among women with a history of preeclampsia. We utilized a two hospital, single academic institution database from August 2011 through June 2016. We excluded multiple gestations and included only the first delivery for women with multiple deliveries during the study period. The cohort of women with a history of preeclampsia were divided into two groups, “before” and “after” the release of the USPSTF 2014 recommendations. Potential confounders were accounted for in multivariate analyses, and relative risk and adjusted relative risk were calculated. RESULTS 17,256 deliveries occurred during the study period. A total of 417 women had a documented history of prior preeclampsia; 284 women “before” and 133 women “after” the USPSTF recommendation. Comparing the before and after groups, the proportion of Hispanic women in the after group was lower and the method of payment differed between the groups (P <.0001). The prevalence of type 1 diabetes was increased in the after period, but overall rates of pregestational diabetes were similar (6.3% before versus 5.3% after; P >.05). Risk factors for recurrent preeclampsia included maternal age >35 years (RR, 1.83; 95% CI, 1.34–2.48), Medicaid insurance (RR, 2.08; 95% CI, 1.15–3.78), type 1 diabetes (RR, 2.13; 95% CI, 1.37–3.33), and chronic hypertension (RR, 1.96; 95% CI, 1.44–2.66). The risk of recurrent preeclampsia was decreased by 30% in the after group (adjusted relative risk (aRR), 0.70; 95% CI, 0.52- 0.95). CONCLUSION Rates of recurrent preeclampsia among women with a history of preeclampsia decreased by 30% after release of the USPSTF recommendation for aspirin for preeclampsia prevention. Future prospective studies should include direct measures of aspirin compliance, gestational age at initiation, and explore the influence of race and ethnicity on the efficacy of this primary prevention.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Tolcher

Chu

Hollier

et al. 2017

American Journal of Obstetrics and Gynecology

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“…Details of this database have been previously published. 17 More than 400 different variables relating to both mothers and their offspring are collected. Regular audits are done to ensure data accuracy.…”

Section: Methodsmentioning

confidence: 99%

Pregnancy Outcomes among Hispanics Stratified by Country of Origin

et al. 2019

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Objective To compare the perinatal outcomes among U.S.-born and foreign-born Hispanics and Caucasians and ascertain if length of time in the US was associated with the rate of adverse outcomes. Study Design Retrospective cohort analysis of gravidae enrolled in our institutional perinatal database. Women delivering a non-anomalous, singleton, at 24 weeks or more and self-identified as Caucasian or Hispanic were included. Women were stratified by country of birth and ethnicity into U.S.-born Caucasian, U.S.-born Hispanic, and U.S. foreign-born Hispanic. Composite maternal (CMM) and neonatal (CNM) morbidity was assessed. Results Of 20,422 women, 21% were Caucasian, 15% were U.S.-born Hispanics, and 64% were U.S. foreign-born Hispanics. Compared to Caucasians, U.S.-born and foreign-born Hispanic were older, more likely to be a grand multiparous, obese and less likely to be married. Compared to Caucasians, foreign-born Hispanics had a 1.42-fold increased risk of CMM (95% CI 1.26–1.30). Paradoxically, the rate of CNM was 40% lower among neonates born to foreign-born Hispanics (95% CI 0.51–0.74). A significant direct relationship was noted between time in the USA and CMM but not CNM among foreign-born Hispanics. Conclusion Despite less favorable baseline characteristics, U.S. foreign-born Hispanics have 40% less CNM compared to both Caucasians and U.S.-born Hispanics.

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“…All subjects delivering at either of these two hospitals were approached, consented, and enrolled at the time of delivery for inclusion in our institutional database, PeriBank. 9 The Baylor College of Medicine maintains a single database that collects information from every delivery pertaining to the pregnancy, the delivery, and the postnatal course. Research coordinators extract this information from direct patient query and the patient charts.…”

Section: Methodsmentioning

confidence: 99%

Platelet Counts in Uncomplicated Pregnancies at Term

2019

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Objective This study aimed to evaluate platelet counts at delivery in uncomplicated pregnancies between 37 and 41 weeks of gestation. Study Design Platelet counts in women 16 to 45 years of age from August 1, 2011, through May 15, 2018, with a singleton pregnancy that delivered from 370/7 to 416/7 weeks of gestation. Women with pregnancy-related complications, preexisting disorders, or on medications that could affect platelet counts were excluded. Results A total of 18,526 women had uncomplicated pregnancies with mean platelet count from 370/7 to 416/7 weeks of gestation of 220 × 109/L. The lower limit 95th percentile (2.5% quantile) was 120 × 109/L. Platelet counts decreased weekly from 37 to 41 weeks of gestation, becoming significant at 39 weeks of gestation and beyond, compared with 37 weeks (p < 0.01). Mean platelet counts: 225 × 109/L at 37 weeks, 223 × 109/L at 38 weeks, 219 × 109/L at 39 weeks, 218 × 109/L at 40 weeks, and 216 × 109/L at 41 weeks of gestation. Platelet counts of less than 150 × 109/L occurred in 9.7%. Conclusion Platelet counts in uncomplicated pregnancies decrease weekly from 37 to 41 weeks of gestation. This will be important to consider when serial platelet values are monitored for other indications.

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Generation and validation of a universal perinatal database and biospecimen repository: PeriBank

Abstract: Here we establish that the creation of a universal perinatal database and biospecimen collection is not only possible, but allows for the performance of state-of-the-science translational perinatal research and is a potentially valuable resource to academic perinatal researchers.

Cited by 39 publications

References 41 publications

Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Pregnancy Outcomes among Hispanics Stratified by Country of Origin

Platelet Counts in Uncomplicated Pregnancies at Term

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