Generation of 4,6-dimethyl-5-[2-(2-methylprop-1-enyl)-1H-benzimidazol-1-yl]pyrimidine-2(5H)-thiones under kinetically controlled phase transfer catalysis conditions

Sharma, Pratibha; Kumar, Ashok; Sharma, Manisha

doi:10.1016/j.molcata.2005.05.003

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…A potent technique for growing their library with various structures and pharmacological qualities is the capacity to boost the diversity of pyrimidine derivatives through coupling processes. [32][33][34][35][36] Given that they allow for the construction of new carboncarbon or carbon-heteroatom bonds and make it possible to add a variety of functional groups and substituents to the pyrimidine core, coupling reactions have successfully diversified pyrimidine derivatives. The pharmacological attributes of pyrimidine derivatives, such as their potency, selectivity, and drug-like qualities, can be improved using this synthesis technique.…”

Section: Diversification Of Pyrimidines Derivativesmentioning

confidence: 99%

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

Ullah,

Shah Bukhari,

Khan

et al. 2023

ChemistrySelect

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Pyrimidine derivatives have attracted much attention in medicinal chemistry because of their diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura, Sonogashira, and Buchwald‐Hartwig coupling reactions provide flexible methods for synthesizing structurally diverse pyrimidine derivatives. These reactions can modify the pyrimidine structure to incorporate different functional groups and substitution patterns, improving the pharmacological activities and maximizing the drug‐like properties. Using other coupling partners, such as aryl and heteroaryl moieties, has produced novel pyrimidine‐based scaffolds with enhanced bioactivity profiles. This comprehensive review examines the biological activities of pyrimidine derivatives, concentrating on how their diversification via coupling reactions utilizing synthetic techniques has affected their pharmacological properties. Investigating various biological effects and exploring novel artificial techniques present great opportunities for creating next‐generation medicines with improved efficacy and selectivity.

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Section: Diversification Of Pyrimidines Derivativesmentioning

confidence: 99%

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

Ullah,

Shah Bukhari,

Khan

et al. 2023

ChemistrySelect

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“…Pyrimidines are generally prepared by the condensation between a three carbon compounds and compounds having the amidine structure (1) where R= OH (urea), SH or SR (thiourea or its s-derivative) in the presence of catalyst sodium hydroxide or sodium ethoxide. This general reaction may be illustrated by the condensation of acetamidine with ethyl acetoacetate (2) to form 4-hydroxy-2,6-dimethylpyrimidine (3) [7].…”

Section: Synthesis Of Pyrimidinesmentioning

confidence: 99%

“…Decarboxylation of malic acid (4) with concentrated sulphuric acid forms a ß-ketoacid (5) which on reaction with urea produces uracil (6). Uracil can be converted to pyrimidine (7) in the following step [8].…”

Section: Synthesis Of Pyrimidinesmentioning

confidence: 99%

An overview on synthesis and biological activity of pyrimidines

Mohamed¹,

Awad²,

El-tawab³

et al. 2022

World J. Adv. Res. Rev.

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Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 of the six membered ring show wide range of biological activities. Numerous methods for the synthesis of pyrimidine and their diverse reactions offer enormous scope in the field of medicinal chemistry. Pyrimidine possesses wide spectrum of biological activities including antitubercular, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, anticancer, and anti-HIV activity. The present review attempts to give brief information about the synthesis and various biological activities of pyrimidines and their derivatives.

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Novel Benzimidazol‐2‐Thione Derivatives: Synthesis, In Vitro Anticancer, Antimicrobial Activities, And In Silico Molecular Docking Study

Phuong

Cương

et al. 2023

ChemistrySelect

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A series of derivative benzimidazol‐2‐thione compounds (2 a–2 l) had been synthesized, screened for their antimicrobial activities by dish diffusion and dilution assays, anti‐tumor against breast, rhabdomyosarcoma, and liver human cancer cell lines via MTT assay, followed by carrying out in silico docking model. Entries 2 i–2 j, 2 l, and 2 g are novel compounds, among them, compound 2i manifested the highest antibacterial activity against both Methicillin‐resistant Staphylococcus aureus and Streptococcus faecalis; meanwhile, entries 2 i–2 j and 2 l showed significant antifungal activity toward Trichophyton mentagrophytes, Trichophyton rubrum, and Microsporum gypseum. Through in vitro approach, entry 2 i is the best derivative against human rhabdomyosarcoma cell line. Additionally, via in silico approach, entry 2 i reasonably explained drug delivery ligand against bacterium Streptococcus faecalis, moreover, entries 2 i–2 j and 2 l showed excellent antifungal activity, explained via enzyme inhibition mechanism against 2VF5. In silico, 2 i was proved to inhibit against sarcoma cancer cell line.

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Generation of 4,6-dimethyl-5-[2-(2-methylprop-1-enyl)-1H-benzimidazol-1-yl]pyrimidine-2(5H)-thiones under kinetically controlled phase transfer catalysis conditions

Cited by 8 publications

References 21 publications

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

An overview on synthesis and biological activity of pyrimidines

Novel Benzimidazol‐2‐Thione Derivatives: Synthesis, In Vitro Anticancer, Antimicrobial Activities, And In Silico Molecular Docking Study

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