Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology

Eksi, Yunus Emre; Bişgin, Atıl; Şanlioğlu, Ahter Dilşad; Azizoglu, Reha Onur; Balcı, Mustafa Kemal; Griffith, Thomas S.; Şanlıoğlu, Salih

doi:10.1007/5584_2022_746

Advances in Experimental Medicine and Biology

2022

DOI: 10.1007/5584_2022_746

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Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology

Yunus Emre Eksi

Atıl Bişgin

Ahter Dilşad Şanlioğlu

et al.

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2024

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Cited by 1 publication

References 55 publications

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Gene and cell therapy of human genetic diseases: Recent advances and future directions

Cetin,

Erendor,

Eksi

et al. 2024

J Cellular Molecular Medi

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Disruptions in normal development and the emergence of health conditions often result from the malfunction of vital genes in the human body. Decades of scientific research have focused on techniques to modify or substitute defective genes with healthy alternatives, marking a new era in disease treatment, prevention and cure. Recent strides in science and technology have reshaped our understanding of disorders, medication development and treatment recommendations, with human gene and cell therapy at the forefront of this transformative shift. Its primary objective is the modification of genes or adjustment of cell behaviour for therapeutic purposes. In this review, we focus on the latest advances in gene and cell therapy for treating human genetic diseases, with a particular emphasis on FDA and EMA‐approved therapies and the evolving landscape of genome editing. We examine the current state of innovative gene editing technologies, particularly the CRISPR‐Cas systems. As we explore the progress, ethical considerations and prospects of these innovations, we gain insight into their potential to revolutionize the treatment of genetic diseases, along with a discussion of the challenges associated with their regulatory pathways. This review traces the origins and evolution of these therapies, from conceptual ideas to practical clinical applications, marking a significant milestone in the field of medical science.

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Gene and cell therapy of human genetic diseases: Recent advances and future directions

Cetin,

Erendor,

Eksi

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

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Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology

Cited by 1 publication

References 55 publications

Gene and cell therapy of human genetic diseases: Recent advances and future directions

Gene and cell therapy of human genetic diseases: Recent advances and future directions

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