Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

Wu, Hong-Yin; Abdu, T. Samira; Stinson, Dana; Russell, Michael W.

doi:10.1128/iai.68.10.5539-5545.2000

Cited by 64 publications

(49 citation statements)

References 49 publications

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“…It remains to be established what mechanisms are operative in other situations of cross-protection, such as protection of the genital tract after nasal priming (10) or possible protection of the gastrointestinal tract after local nasal priming.…”

Section: Discussionmentioning

confidence: 99%

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Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

Zuercher

Jiang

Thurnheer

et al. 2002

The Journal of Immunology

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A main feature of the common mucosal immune system is that lymphocytes primed in one mucosal inductive site may home to distant mucosal effector sites. However, the mechanisms responsible for such cross-protection remain elusive. To address these we have used a model of local mucosal infection of mice with reovirus. In immunocompetent mice local duodenal priming protected against subsequent respiratory challenge. In the upper respiratory tract this protection appeared to be mainly mediated by specific IgA- and IgG2a-producing B cells, whereas ex vivo active effector memory CTL were found in the lower respiratory tract. In accordance with these findings, clearance of reovirus from the lower respiratory tract, but not from the upper respiratory tract, of infected SCID mice upon transfer of gut-primed lymphocytes depended on the presence of T cells. Taken together this study reveals that intestinal priming leads to protection of both the upper and lower respiratory tracts, however through distinct mechanisms. We suggest that cross-protection in the common mucosal immune system is mediated by trafficking of B cells and effector memory CTL.

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Section: Discussionmentioning

confidence: 99%

“…Similarly, it is now established that oral (5,9) or intranasal (i.n.) (10) vaccination can elicit production of specific Ab in the female genital tract.…”

Section: T Ransfer Of Either Peyer's Patch (Pp)mentioning

confidence: 99%

Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

Zuercher

Jiang

Thurnheer

et al. 2002

The Journal of Immunology

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“…Given this distinct advantage, recent vaccine strategies have focused on intranasal (i.n.) 3 immunizations as an effective means for stimulating reproductive tract (RT) immunity (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). This indirect method of vaccination, in addition to ease of administration, circumvents concerns regarding epithelial cell turnover and hormonal influences within the RT (13).…”

mentioning

confidence: 99%

Absence of L-Selectin Delays Mucosal B Cell Responses in Nonintestinal Effector Tissues

Csencsits

Pascual

2002

The Journal of Immunology

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Previous studies suggest that lymphocyte trafficking to head and neck lymph nodes, also referred to as cranial-, oral-, nasal-associated lymphoid tissue (CONALT), is L-selectin (L-Sel) dependent, despite coexpression of α4β7, resulting in their marked reduction in L-Sel-deficient (L-Sel−/−) mice. Consequently, early phase (16 days) Ab responses to cholera toxin (CT) are diminished. The following studies reveal that lack of mucosal effector responses is not caused by loss of inductive immune responses in the L-Sel−/− CONALT. Indeed, there was an increased accumulation of total IgA, but not Ag-specific IgA Ab-forming cells (AFC) in L-Sel−/− CONALT. This increased accumulation was not evident in L-Sel+/+ CONALT. Identification of lymphocyte-homing receptors on L-Sel−/− and L-Sel+/+ CONALT lymphocytes revealed no significant differences in expression of α4β7, which might contribute to lymphocyte homing in the absence of L-Sel. Studies of CONALT responses during the late phase (6 wk post-intranasal immunization) revealed the number of lymphocytes recovered from L-Sel−/− CONALT was less than L-Sel+/+ CONALT; however, L-Sel−/− CT-specific and total AFC did not vary from 16-day responses, suggesting a defect in CT-specific B cell export. No significant differences in α4β7 expression between L-Sel−/− and L-Sel+/+ CONALT were noted. Yet, these increases in CONALT AFC correlated with restoration of immunity in L-Sel−/− nasal passages and reproductive tracts.

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“…Indeed, systemic immunization has been shown to induce high levels of specific antibodies in the genitourinary tract. 5,14,17,71 Lastly, homing of B cells to the cervix may allow rescue of B cells with potentially auto-reactive specificity to forbidden epitopes on HIV-1 generated by systemic immunization to the external mucosal environment. 72 The authors note that some level of caution should be taken in extrapolating somatic mutation and mucosal-systemic B-cell trafficking patterns from repertoire analysis conducted on B cells from a single individual.…”

confidence: 99%

Molecular characterization of the cervical and systemic B-cell repertoire

Gaudet

Breden

Plummer

et al. 2011

mAbs

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Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

Cited by 64 publications

References 49 publications

Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

Absence of L-Selectin Delays Mucosal B Cell Responses in Nonintestinal Effector Tissues

Molecular characterization of the cervical and systemic B-cell repertoire

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