Generation of hypoxia-sensing chimeric antigen receptor T cells

Kosti, Paris; Larios-Martinez, Karen I.; Maher, John; Arnold, James N.

doi:10.1016/j.xpro.2021.100723

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…The promising efficacy of this approach has been proven in vitro and in vivo, overcoming two main limitations, i.e., a more stringent control of CAR expression and a greater anti-tumor activity with no apparent on-target/off-tumor toxicity. In addition, a gene panel including VEGFA, PGK1 , CA9 , SLC2A1, and ALDOA has been proposed to select those patients who could best benefit from this promising approach [ 215 ]. He et al .…”

Section: Genome Editing and Hypoxia-response Pathwaymentioning

confidence: 99%

Genome editing and cancer therapy: handling the hypoxia-responsive pathway as a promising strategy

Stampone

Bencivenga

Capellupo

et al. 2023

Cell. Mol. Life Sci.

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The precise characterization of oxygen-sensing pathways and the identification of pO2-regulated gene expression are both issues of critical importance. The O2-sensing system plays crucial roles in almost all the pivotal human processes, including the stem cell specification, the growth and development of tissues (such as embryogenesis), the modulation of intermediate metabolism (including the shift of the glucose metabolism from oxidative to anaerobic ATP production and vice versa), and the control of blood pressure. The solid cancer microenvironment is characterized by low oxygen levels and by the consequent activation of the hypoxia response that, in turn, allows a complex adaptive response characterized mainly by neoangiogenesis and metabolic reprogramming. Recently, incredible advances in molecular genetic methodologies allowed the genome editing with high efficiency and, above all, the precise identification of target cells/tissues. These new possibilities and the knowledge of the mechanisms of adaptation to hypoxia suggest the effective development of new therapeutic approaches based on the manipulation, targeting, and exploitation of the oxygen-sensor system molecular mechanisms.

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Section: Genome Editing and Hypoxia-response Pathwaymentioning

confidence: 99%