Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody–containing plasma unit that was associated with severe nonhemolytic transfusion reactions

Sakagawa, Hisako; Miyazaki, Tôru; Fujihara, Mitsuhiro; Sato, Shin-ichiro; Miki, Yoshio; Fukai, Kanji; Morioka, Masanobu; Kato, Toshiaki; Azuma, Hiroshi; Ikeda, Hisami

doi:10.1111/j.1537-2995.2007.01078.x

Cited by 29 publications

(41 citation statements)

References 26 publications

(41 reference statements)

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“…LPS is a well-known activator of monocytes/macrophages, causing production of inflammatory cytokines and chemokines [34]. PBMNCs from all subjects, including two with irrelevant HLA-DR antigens, responded to LPS similarly, producing a high level of each cytokine or chemokine [32]. From these results, we can conclude that anti-HLA-DR Ab-containing plasma has the ability to produce inflammatory cytokines and chemokines by PBMNCs in a cognate antigen-antibody interaction [32].…”

Section: Production Of Inflammatory Cytokines and Chemokines By Pbmncmentioning

confidence: 59%

“…Based upon the findings obtained in our in vitro experiments [32,33,42], we propose a mechanism by which anti-HLA class II Ab may contribute to the pathology of TRALI, as illustrated in Fig. (3).…”

Section: Conclusion and Perspectivementioning

confidence: 99%

“…Studies using monoclonal Abs (mAbs) against human Fc Rs show that Fc RII (CD32) mAb (clone 7.3) and anti-Fc RIII (CD16) mAb (clone 3G8) substantially reduced the production of IL-1 and IL-6 by PBMNCs in response to anti-HLA-DR Ab-containing plasma, while anti-Fc RI (CD64) mAb (clone 32.2) had no significant inhibitory effect on these two cytokines [32]. These results suggest that Fc RII (CD32) and/or Fc RIII (CD16) are involved in the anti-HLA-DR Ab-containing plasma-triggered production of inflammatory cytokines by relevant PBMNCs [32].…”

Section: Requirement Of Fc R For Production Of Inflammatory Cytokinesmentioning

confidence: 99%

“…In addition, it did not react with the plasma proteins tested. The donor serum did not react with healthy volunteers with HLA-DR (1, 15) [32]. Based on these laboratory tests, this donor plasma was referred to as "anti-HLA-DR Abcontaining plasma" [32].…”

Section: Expression Of Inflammatory Cytokines and Chemokines By Pbmncmentioning

confidence: 99%

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Involvement of Human Leukocyte Antigen Class II Antibody in Pathogenesis of Transfusion-Related Acute Lung Injury (TRALI): Vascular Permeability Enhancement

Fujihara¹,

Wakamoto²,

Azuma³

et al. 2009

VDP

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Vascular endothelial cells regulate the passage of fluids, solutes, and cells from the vascular space to the tissues. Disruption of vascular integrity is involved in the pathogenesis of inflammatory diseases including transfusionrelated acute lung injury (TRALI), a most severe nonhemolytic transfusion reaction with symptoms such as dyspnea and/or hypotension and fever. Pulmonary edema, due to increased vascular permeability for macromolecules and plasma, is a hallmark of TRALI. The mortality rate of TRALI ranges from 5 to 10%. While donor antibodies (Abs) against human leukocyte antigen (HLA) class I and granulocytes are regarded as causative factors, various clinical studies have demonstrated the roles of anti-HLA class II-Ab on the etiology of TRALI, although the detailed mechanisms have not been clarified. Over several years we have investigated to clarify the underlying mechanism by which anti-HLA class II Abs cause an increase in endothelial permeability. In this review, we show that anti-HLA class II Ab generates proinflammatory cytokines and chemokines from HLA class II positive mononuclear cells of peripheral blood in an Fc R-dependent manner. As a result, the produced interleukin-1 and tumor necrosis factor-lead to increased endothelial permeability via the nuclear factor-B pathway but not apoptosis of endothelial cells. These findings provide a better understanding of the roles of anti-HLA class II Ab in the etiology of TRALI.

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Section: Production Of Inflammatory Cytokines and Chemokines By Pbmncmentioning

confidence: 59%

Section: Conclusion and Perspectivementioning

confidence: 99%

Section: Requirement Of Fc R For Production Of Inflammatory Cytokinesmentioning

confidence: 99%

Section: Expression Of Inflammatory Cytokines and Chemokines By Pbmncmentioning

confidence: 99%

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Involvement of Human Leukocyte Antigen Class II Antibody in Pathogenesis of Transfusion-Related Acute Lung Injury (TRALI): Vascular Permeability Enhancement

Fujihara¹,

Wakamoto²,

Azuma³

et al. 2009

VDP

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“…In the setting of a non-haemolytic transfusion reaction with fever, chills, pain and dyspnoea that was associated with transfusion of plasma containing human leucocyte antigen DR antibodies reactive with recipient specificities, CXCL1 and CXCL8 have been implicated [56]. In vitro incubation of antigen positive peripheral blood mononuclear cells resulted in chemokine expression, as well as production of TNF-α , IL-1 β and IL-6.…”

Section: Transfusion Reactionsmentioning

confidence: 99%

An introduction to chemokines and their roles in transfusion medicine

Davenport

2009

Vox Sanguinis

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Chemokines are a set of structurally related peptides that were first characterized as chemoattractants and have subsequently been shown to have many functions in homeostasis and pathophysiology. Diversity and redundancy of chemokine function is imparted by both selectivity and overlap in the specificity of chemokine receptors for their ligands. Chemokines have roles impacting transfusion medicine in haematopoiesis, haematologic malignancies, transfusion reactions, graft-versus-host disease, and viral infections. In haematopoietic cell transplantation, chemokines are active in mobilization and homing of progenitor cells, as well as mediating T-cell recruitment in graft-versus-host disease. Platelets are rich source of chemokines that recruit and activate leucocytes during thrombosis. Important transfusion-transmissible viruses such as cytomegalovirus and human immunodeficiency virus exploit chemokine receptors to evade host immunity. Chemokines may also have roles in the pathophysiology of haemolytic and non-haemolytic transfusion reactions.

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Platelet Transfusion

Meledeo¹,

Thomas²,

Bynum³

et al. 2020

Trauma Induced Coagulopathy

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Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody–containing plasma unit that was associated with severe nonhemolytic transfusion reactions

Abstract: HLA-DR antibodies, detected in this case, had biologic functions to induce production of not only inflammatory cytokines but also neutrophil-attractant chemokines in vitro, which could contribute to the etiology of severe nonhemolytic transfusion reactions.

Cited by 29 publications

References 26 publications

Involvement of Human Leukocyte Antigen Class II Antibody in Pathogenesis of Transfusion-Related Acute Lung Injury (TRALI): Vascular Permeability Enhancement

Involvement of Human Leukocyte Antigen Class II Antibody in Pathogenesis of Transfusion-Related Acute Lung Injury (TRALI): Vascular Permeability Enhancement

An introduction to chemokines and their roles in transfusion medicine

Platelet Transfusion

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