Generation of Linear and Parabolic Concentration Gradients by Using a Christmas Tree-Shaped Microfluidic Network

Shen, Qilong; Zhou, Qiongwei; Lu, Zhigang; Zhang, Nangang

doi:10.1007/s11859-018-1317-y

Cited by 7 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…M ICROFLUIDIC concentration gradient generators are important components for biological and chemical research [1,2,3,4,5,6] due to their ability to create spatially resolved concentration values allowing to screen a wide range of concentrations at the same time. Especially tree-shaped gradient generators, comprised of branching, mixing, and recombining channels [7,8,9,10,11,12,13,14,15,16,17,18], are commonly used due to their flexibility in concentration values and their ability to maintain the gradient profile indefinitely [6].…”

Section: Introductionmentioning

confidence: 99%

Automatic Design of Microfluidic Gradient Generators

et al. 2022

View full text Add to dashboard Cite

Concentration gradient generators are common components of microfluidic devices when specified mixing ratios have to be acquired. However, depending on their complexity, the creation of a suitable design is an elaborate task. Although approaches exist that derive such a design, they suffer from low flexibility and usability, which is why most concentration gradient generators are still mainly designed manually thus far-a time-consuming and error-prone task. To tackle this problem, we propose a method for the automatic design of tree-shaped concentration gradient generators and introduce a publicly available online tool that automatically generates a suitable design by adjusting the hydrodynamic resistances within the network. Moreover, the proposed tool is not only able to generate designs complying with user-defined requirements, such as mixing ratios, flow rates, and channel widths but also works for any number of outlets. Simulations using a Computational Fluid Dynamics (CFD) tool as well as evaluations on fabricated designs confirm the quality of the results obtained by the proposed tool.

show abstract