Generation of microcellular biodegradable polycaprolactone foams in supercritical carbon dioxide

Xu, Qun; Ren, Xianwen; Chang, Ying; Wang, Jingwu; Yu, Long; Dean, Katherine

doi:10.1002/app.20726

Cited by 74 publications

(51 citation statements)

References 15 publications

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“…Polycaprolactone (PCL) is a resorbable polymer that has been used to make surgical implants and tissue engineering scaffolds [1][2][3][4]. One of its advantages is that it has a slower rate of hydrolysis than the competitor materials polyglycolic acid (PGA) and polylactic acid (PLA) [1].…”

Section: Introductionmentioning

confidence: 99%

“…for surgical repair of tissues, it will be necessary to sterilise scaffolds by methods that are conventionally used for other implants. Scaffolds usually have porous structures [2][3][4], so a sterilisation method is required that can penetrate such a material without leaving residues that could, for example, affect the ability of cells to attach and grow. Gamma irradiation is highly penetrative.…”

Section: Introductionmentioning

confidence: 99%

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Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

Cottam

Hukins

Lee

et al. 2009

Medical Engineering & Physics

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

Cottam

Hukins

Lee

et al. 2009

Medical Engineering & Physics

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“…During the expansion process, the morphology of the scaffold may be generated by implementing a heterogeneous nucleation with, for example, closed cell foams and microsizes of approximately 10 µm [156] or a homogeneous nucleation with cell sizes in a broad range of 30-700 µm [157]. It has been published regularly that the foams possess closed cells [158][159][160], however, this means, at the same time, that there is a low level of interconnectivity and therefore their application in the area of tissue engineering is limited.…”

Section: Scaffold Preparation From the Polymer Melt By A Foaming Processmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

210

154

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Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

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“…Until now, the focus of research was to investigate the influence of the microstructure, 8 -14,20 -26,34,35 thermal properties, 20,35 tensile strength, 9,16,36 impact strength, 5,15 compression strength, and any other mechanical properties. However, the electrical properties of microcellular PC sheets are also investigated in this article, which will facilitate their application in the electronics industry in the near future.…”

Section: Microcellular Foam Was Invented At the Massachusettsmentioning

confidence: 99%

Preparation and characterization of microcellular thin polycarbonate sheets

Xiang

Guan

Fang

et al. 2005

J of Applied Polymer Sci

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A new method was developed for the microcellular processing of polycarbonate (PC) thin sheets by compression molding above PC's glass-transition temperature and below its melting temperature within a few minutes. The effects of the foaming time, foaming pressure, foaming temperature, and foaming agent active ratio on the cell size, cell density, and relative density were studied. The structures of the microcellular PC foam were controlled in the foaming process by carefully choosing the foaming parameters. In addition, the thermal, dynamic mechanical thermal, and electrical properties of the microcellular PC foam were investigated. A differential scanning calorimetry analysis showed that the microcellularly processed PC may have a plastication effect. The variation of the storage modulus, loss modulus, and tan ␦ under dynamic mechanical thermal analysis was in accord with the calorimetry analysis. The measurement of the electrical property demonstrated that the insulation ability of the microcellular PC thin sheet was obviously enhanced and the dielectric strength of the microcellular PC foam was decreased compared to the unfoamed PC.

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Generation of microcellular biodegradable polycaprolactone foams in supercritical carbon dioxide

Cited by 74 publications

References 15 publications

Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

Design and preparation of polymeric scaffolds for tissue engineering

Preparation and characterization of microcellular thin polycarbonate sheets

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