In this study, the quantum-memory assisted entropic uncertainty (QM-EU) and entanglement dynamics of the two-qubit Heisenberg XXX chain have been explored in the presence of intrinsic decoherence. The effect of the x-component of Dzyaloshinskii-Moriya (DM) and Kaplan-Shekhtman-Entin-Wohlman-Aharony (KSEA) interactions has been considered. The generation and preservation of quantum memory and entanglement have been examined for various values of the DM, KSEA, spin-spin, and spin coupling strengths. The uncertainty negatively affects the entanglement and both have anti-correlation. The absence and presence of intrinsic decoherence prevail in differing impacts on the dynamics of the system. In the first case, prolonged entanglement preservation, uncertainty suppression, and oscillatory dynamics have been observed. Moreover, in order to achieve the best-prolonged entanglement preservation and relative reduction of the entropic uncertainty, we have analyzed several parameter settings. We find that the effects of raising the DM, KSEA, and spin-spin interaction individually and simultaneously are different. The individual and simultaneous increase of the DM, KSEA, and spin-spin interaction parameters control the degree of entanglement, entropic uncertainty, and primarily the dynamics of the system.