Hybrid quantum gates have recently drawn considerable attention. They play significant roles in connecting quantum information processors with qubits of different encoding and have important applications in the transmission of quantum states between a quantum processor and a quantum memory. In this work, we propose a single-step implementation of a multi-target-qubit controlled-NOT gate with one superconducting (SC) qubit simultaneously controlling n target cat-state qubits. In this proposal, the gate is implemented with n microwave cavities coupled to a three-level SC qutrit. The two logic states of the control SC qubit are represented by the two lowest levels of the qutrit, while the two logic states of each target cat-state qubit are represented by two quasi-orthogonal cat states of a microwave cavity. This proposal operates essentially through the dispersive coupling of each cavity with the qutrit. The gate realization is quite simple because it requires only a single-step operation. There is no need of applying a classical pulse or performing a measurement. The gate operation time is independent of the number of target qubits, thus it does not increase as the number of target qubits increases. Moreover, because the third higher energy level of the qutrit is not occupied during the gate operation, decoherence from the qutrit is greatly suppressed. As an application of this hybrid multi-target-qubit gate, we further discuss the generation of a hybrid Greenberger-Horne-Zeilinger (GHZ) entangled state of SC qubits and cat-state qubits. As an example, we numerically analyze the experimental feasibility of generating a hybrid GHZ state of one SC qubit and three cat-state qubits within present circuit QED technology. This proposal is quite general and can be extended to implement a hybrid controlled-NOT gate with one matter qubit (of different type) simultaneously controlling multiple target cat-state qubits in a wide range of physical systems, such as multiple microwave or optical cavities coupled to a three-level natural or artificial atom.