Generic Deterministic Models of Prokaryotic Gene Regulation

Mackey, Michael C.; Santillán, Moisés; Tyran‐Kamińska, Marta; Zeron, Eduardo S.

doi:10.1007/978-3-319-45318-7_1

Cited by 1 publication

(1 citation statement)

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“…Mathematical modeling has long accompanied research on molecular decision-making [ 3 , 4 , 5 , 6 ]. Corresponding models contributed particularly to the understanding of switch-like decisions in bacteria, as they commonly occur in response to changing environmental conditions [ 7 ]. In seminal work, Gardner et al [ 8 ] took a reductionist approach to demonstrate how a synthetic genetic toggle switch built on the mutual interaction of two repressible operons establishes bistability and exemplifies the minimal requirements of a binary molecular decision-making process, in which the choice of one option intrinsically represses the other.…”

Section: Stem Cell Decision-making and The Concept Of Bistabilitymentioning

confidence: 99%

Mechanistic models of blood cell fate decisions in the era of single-cell data

Glauche

Marr

2021

Current Opinion in Systems Biology

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Billions of functionally distinct blood cells emerge from a pool of hematopoietic stem cells in our bodies every day. This progressive differentiation process is hierarchically structured and remarkably robust. We provide an introductory review to mathematical approaches addressing the functional aspects of how lineage choice is potentially implemented on a molecular level. Emerging from studies on the mutual repression of key transcription factors, we illustrate how those simple concepts have been challenged in recent years and subsequently extended. Especially, the analysis of omics data on the single-cell level with computational tools provides descriptive insights on a yet unknown level, while their embedding into a consistent mechanistic and mathematical framework is still incomplete.

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