Based on recent work of Kaletha, we apply Hakim-Murnaghan theory to study distinguished regular supercuspidal representations of tamely ramified p-adic reductive groups. Assuming p is sufficiently large, we obtain a necessary and sufficient condition for regular supercuspidal representations to be distinguished. We also investigate the relation between distinction and Langlands functoriality, and confirm a conjecture of Lapid for regular depth-zero or epipelagic supercuspidal representations.