Genes Conferring Antimicrobial-Resistance Among Klebsiella Pneumoniae in the Arabian Gulf Countries: A Systematic Review and Meta-Analysis

Bindayna, Khalid Mubarak; Joji, Ronni Mol; Ezzat, Hicham; Jahrami, Haitham

doi:10.22159/ajpcr.2021.v14i4.40841

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…CTX-M-type ESBLs have been detected in various strains of Klebsiella species, including Klebsiella pneumoniae, Klebsiella oxytoca, and Klebsiella planticola. These enzymes are often responsible for mediating resistance to cephalosporins and can contribute to the challenge of treating infections caused by these bacteria [10].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Ecological Distribution and Antibiotic Resistance Profiles of Klebsiella Species in Diverse Environmental Niches

Mahdi

2024

JMGCB

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Antimicrobial resistance is a growing problem in bacterial pathogens, particularly in hospital-acquired nosocomial infections. Klebsiella is an important pathogen that causes various infections in hospitalized immunocompromised patients. Therefore, this study aims to fill this knowledge gap and provide insights into the correct detection and antibiotic resistance pattern of these organisms. we will investigate the spread of pneumonia bacteria, Klebsiella, isolate and identify it from different environmental sites, including human, soil, and water, also study the characteristics of antibiotic resistance and find similarities and differences between bacterial isolates. Finally, we detect the associated antibiotics resistance gene (CTX-M), using the genetic RT-PCR method. The study provides valuable information on the prevalence of antibiotic resistant Klebsiella spp. in different clinical and environmental sites, which can help in the development of effective strategies to control the spread of these bacteria. The study found that among all 86 isolated strains of Klebsiella spp. it was found that K. pneumoniae represents the major abundant strain in both clinical and environmental samples by percentages 41.5% and 51.5% respectively. It concerns also the highest ESBL production 71.7%, along with 58% CTX-M gene expression

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Section: Introductionmentioning

confidence: 99%

Exploring the Ecological Distribution and Antibiotic Resistance Profiles of Klebsiella Species in Diverse Environmental Niches

Mahdi

2024

JMGCB

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Correlation between Antibiotics-Resistance, Virulence Genes and Genotypes among Klebsiella pneumoniae Clinical Strains Isolated in Guangzhou, China

Hu,

Bi,

Zhang

et al. 2024

Curr Microbiol

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CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

Al-Mogbel

Altheban

Alenezi³

et al. 2021

IDR

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Objective The aim of this study was to retrospectively characterize E. coli and K. pneumoniae isolates obtained from neonates during a suspected NICU outbreak of infection in Ha’il, Saudi Arabia during a period of one month (April 2014). Methods Antibiotic susceptibility patterns, molecular characterization for antibiotic-resistant genes ( bla TEM, bla SHV, and bla CTX-M), and genotyping by PFGE and MLST were performed. Results A total of 24 E. coli and 48 K. pneumoniae isolates were cultured from neonates that had been admitted to the NICU. Among E. coli , the majority of isolates (19/24) were ESBL-positive and all of these nineteen (100%) harbored the CTX-M-15 gene. A total of 15% (3/19) were co-producers of CTX-M-15 and SHV-12, and 68.4% (13/19) were co-producers of CTX-M-15 and TEM-1. Among K. pneumoniae isolates, 87.5% (42/48) were ESBL positive with 92.85% (39/42) of these isolates containing the CTX-M-15 gene. A total of 97% (38/39) of K. pneumoniae were co-producers of CTX-M-15 and SHV-12, and 88% (37/42) were positive for TEM-1. Furthermore, 85.7% (36/42) K. pneumoniae were co-producers of CTX-M-15 and TEM-1. The majority of E. coli isolates (18/19 isolates) were grouped into two genetic clusters by pulsed field gel electrophoresis (PFGE) and all the isolates were found to be ST-131 type. In contrast, K. pneumoniae (31/42) isolates belonged to a single genotypic lineage, and all (100%) isolates belonged to the ST-14 type. Conclusion This is the first report of CTX-M-15-positive, ESBL E. coli , and K. pneumoniae isolates recovered from an outbreak in an NICU in Ha’il, Saudi Arabia. It is alarming to note the high rate of outbreak isolates with simultaneous production of CTX-M-15 and SHV-12 conferring high-level resistance to oxyimino-cephalosporins.

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Genes Conferring Antimicrobial-Resistance Among Klebsiella Pneumoniae in the Arabian Gulf Countries: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 24 publications

Exploring the Ecological Distribution and Antibiotic Resistance Profiles of Klebsiella Species in Diverse Environmental Niches

Exploring the Ecological Distribution and Antibiotic Resistance Profiles of Klebsiella Species in Diverse Environmental Niches

Correlation between Antibiotics-Resistance, Virulence Genes and Genotypes among Klebsiella pneumoniae Clinical Strains Isolated in Guangzhou, China

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

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