2014
DOI: 10.1002/evan.21409
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Genes, development, and evolvability in primate evolution

Abstract: Development is the process whereby a fertilized cell becomes a mature individual. In metazoans, this complex process involves the differentiation of somatic cells into committed cell and tissue types; the organization and migration of cells, tissues, and anatomical structures relative to one another; and growth. Development matters to evolution in two ways. First, development carries out heritable genetic instructions contained in zygotes to produce functioning yet phenotypically varied individuals. At the pop… Show more

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Cited by 54 publications
(55 citation statements)
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“…Limbs have a complex polygenic basis. They are found to be highly genetically correlated and exhibit strong pleiotropy when studied in a quantitative genetic framework (21,(41)(42)(43). When sample sizes are sufficient to render precise estimates of genetic correlations for morphological characters, the genetic and phenotypic correlations are nearly identical, implying a high degree of proportionality between genetic and phenotypic covariances (44,45).…”
Section: Discussionmentioning
confidence: 99%
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“…Limbs have a complex polygenic basis. They are found to be highly genetically correlated and exhibit strong pleiotropy when studied in a quantitative genetic framework (21,(41)(42)(43). When sample sizes are sufficient to render precise estimates of genetic correlations for morphological characters, the genetic and phenotypic correlations are nearly identical, implying a high degree of proportionality between genetic and phenotypic covariances (44,45).…”
Section: Discussionmentioning
confidence: 99%
“…1 (adapted with permission from ref. 21) shows this contrast graphically: if traits are uncorrelated, then they will respond to selection in the same direction as the force of selection irrespective of what direction in the morphospace selection is acting (Fig. 1A).…”
mentioning
confidence: 99%
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“…). For example, complex regulatory domains controlling Hox gene expression can produce modular changes in limb length and vertebral identity . In addition, limb growth has been shown to be affected by specific enhancers for another hind limb selector gene, Tbx4 .…”
Section: Significance For Hominoid Evolutionary Historymentioning
confidence: 99%
“…First, there is a growing realization within evolutionary anthropology that the primate skeleton represents a complex, integrated system with varying levels of modularity based on genetic, developmental, and functional factors . Therefore, there is an urgent need to assimilate the multivariate form of different aspects of the skeleton (cranium and postcranium) in evolutionary studies so that we can build a better understanding of what the morphological units of evolution might be.…”
Section: Conceptual Stumbling Blocks In the Evolutionary Analysis Of mentioning
confidence: 99%