Genes, emotions and gut microbiota: The next frontier for the gastroenterologist

Panduro, Arturo; Rivera-Iñiguez, Ingrid; Sepúlveda-Villegas, Maricruz; Román, Sonia

doi:10.3748/wjg.v23.i17.3030

Cited by 46 publications

(33 citation statements)

References 115 publications

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“…An integrative approach between nutrigenetic, agronomy/culinary and behavioral nutrition research is required to provide the knowledge that we need to prevent and treat NR-NCD [ 65 , 66 , 67 ]. Therefore, the prevalence profile of the DRAG polymorphisms presented herein as well as others previously assessed may aid to define the genetic diversity of the Mexican genome and its linkage to NR-NCD [ 68 , 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms

Ojeda‐Granados

Panduro

González-Aldaco

et al. 2017

JPM

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Diet-related adaptive gene (DRAG) polymorphisms identified in specific populations are associated with chronic disorders in carriers of the adaptive alleles due to changes in dietary and lifestyle patterns in recent times. Mexico’s population is comprised of Amerindians (AM) and Mestizos who have variable AM, European (EUR) and African genetic ancestry and an increased risk of nutrition-related chronic diseases. Nutritional advice based on the Mexican genome and the traditional food culture is needed to develop preventive and therapeutic strategies. Therefore, we aimed to provide a prevalence profile of several DRAG polymorphisms in the Mexican population, including Central West (CW) Mexico subpopulations. Geographic heat maps were built using ArcGIS10 (Esri, Redlands, CA, USA) software, based on the published data of the MTHFR C677T (rs1801133), ABCA1 Arg230Cys (rs9282541), APOE T388C (rs429358)/C526T (rs7412), LCT C-13910T (rs4988235) polymorphisms and AMY1 copy number variation (CNV). Also, new data obtained by allelic discrimination-real-time polymerase chain reaction (RT-PCR) assays for the MTHFR, ABCA1, and APOE polymorphisms as well as the AMY1 CNV in the CW Mexico subpopulations with different proportions of AM and EUR ancestry were included. In the CW region, the highest frequency of the MTHFR 677T, ABCA1 230C and APOE ε4 adaptive alleles was observed in the AM groups, followed by Mestizos with intermediate AM ancestry. The LCT-13910T allele frequency was highest in Mestizos-EUR but extremely low in AM, while the AMY1 diploid copy number was 6.82 ± 3.3 copies. Overall, the heat maps showed a heterogeneous distribution of the DRAG polymorphisms, in which the AM groups revealed the highest frequencies of the adaptive alleles followed by Mestizos. Given these genetic differences, genome-based nutritional advice should be tailored in a regionalized and individualized manner according to the available foods and Mexican traditional food culture that may lead to a healthier dietary pattern.

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Section: Discussionmentioning

confidence: 99%

Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms

Ojeda‐Granados

Panduro

González-Aldaco

et al. 2017

JPM

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“…Most studies to date have focused on the impact of drug use on the gut microbiota. In addition to drugs of abuse having a direct effect on gut microbiota (1193), addiction includes a myriad of comorbidities that have previously been linked to the microbiota-gut-brain axis, including stress and anxiety (88,209,229,1635), depression (413,1470), and chronic inflammation (37,872,906,925,1151).…”

Section: G Addictionmentioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,993

2,066

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The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

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“…As was pointed out recently, “the gastrointestinal system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. … an integrated approach … is the next frontier that awaits the gastroenterologist to prevent and treat GI disorders” 152 .…”

Section: Closing Remarksmentioning

confidence: 99%

The stress concept in gastroenterology: from Selye to today

Elsenbruch

Enck²

2017

F1000Res

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More than eighty years after Hans Selye (1907–1982) first developed a concept describing how different types of environmental stressors affect physiological functions and promote disease development (called the “general adaptation syndrome”) in 1936, we herein review advances in theoretical, mechanistic, and clinical knowledge in stress research, especially in the area of gastroenterology, and summarize progress and future perspectives arising from an interdisciplinary psychoneurobiological framework in which genetics, epigenetics, and other advanced ( omics) technologies in the last decade continue to refine knowledge about how stress affects the brain-gut axis in health and gastrointestinal disease. We demonstrate that neurobiological stress research continues to be a driving force for scientific progress in gastroenterology and related clinical areas, inspiring translational research from animal models to clinical applications, while highlighting some areas that remain incompletely understood, such as the roles of sex/gender and gut microbiota in health and disease. Future directions of research should include not only the genetics of the stress response and resilience but also epigenetic contributions.

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Genes, emotions and gut microbiota: The next frontier for the gastroenterologist

Cited by 46 publications

References 115 publications

Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms

Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms

The Microbiota-Gut-Brain Axis

The stress concept in gastroenterology: from Selye to today

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