Genes, Environments, Personality, and Successful Aging: Toward a Comprehensive Developmental Model in Later Life

Eaton, Nicholas R.; Krueger, Robert F.; South, Susan C.; Gruenewald, Tara L.; Seeman, Teresa E.; Roberts, Brent W.

doi:10.1093/gerona/gls090

Cited by 40 publications

(25 citation statements)

References 35 publications

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“…Longevity is a complex phenotype arising from multiple variables, and genetic background plays a pivotal role not only for a deterministic control on hereditary disorders, but also in modulating the individual response to environmental hits and drug therapies (Eaton et al 2012;Murabito et al 2012;Chung et al 2010;Seripa et al 2010). Genes with involvement in basic physiologic Fig.…”

Section: Discussionmentioning

confidence: 99%

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

Albani

Ateri

Mazzuco

et al. 2013

AGE

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Human sirtuins are seven proteins with deacetylase activity that are emerging as key modulators of basic physiological functions. Some evidence links SIRT3 to longevity in mammals. This study aimed to investigate whether variants within SIRT3 gene were associated to human longevity. We analyzed 549 genomic DNA collected during the prospective study "Treviso Longeva," including elderly over 70 years of AGE (2014) age from the municipality of Treviso, a small city in the northeast of Italy. We genotyped SIRT3 rs3825075, rs4980329, and rs11555236 single nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction allelic discrimination assay. A cross-sectional analysis performed by comparing people over and under 85 years of age did not evidence association among the SIRT3 SNPs and longevity. However, when we performed a longitudinal analysis considering mortality as a dependent variable, we observed an association of SIRT3 rs11555236 and rs4980329 with longevity in the whole population (p values corrected for potential confounders=0.04 and 0.03, respectively). After stratification according to gender, the same SNPs were associated to female longevity only (p values corrected for potential confounders=0.03 and 0.02, respectively). Finally, as rs11555236 was reported to be in linkage disequilibrium with a putative functional enhancer within the SIRT3 gene, we assessed whether rs11555236 genotypes correlated with a different level of SIRT3 protein in peripheral blood mononuclear cells. We found an increased level of SIRT3 in subjects homozygous for the (T) allele. We suggest that SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population.

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Section: Discussionmentioning

confidence: 99%

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

Albani

Ateri

Mazzuco

et al. 2013

AGE

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“…This might be due to non-specific disease susceptibility presumably acting through insufficient immune response [12]. It is also possible, that some genes exert their influence on longevity through personality traits, such as conscientiousness and some of its facets (responsibility, self-control and traditionalism) which have been shown to be significant predictors of extended life-span [13]. …”

Section: Introductionmentioning

confidence: 99%

Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene

et al. 2016

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Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90–109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18–97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18–75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating non-disease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.

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“…2 Individual factors such as genes, gender and age have an effect on weight, obesity and health behaviors in general. 3,4 However, the ecological framework of health promotion states that social and physical environmental factors also influence health behaviors. 5 Part of the physical environment influencing health behaviors, such as food choices, is the food environment, which has been conceptualized to include any opportunity to obtain food.…”

Section: Introductionmentioning

confidence: 99%

Association between home and school food environments and dietary patterns among 9–11-year-old children in 12 countries

et al. 2015

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Genes, Environments, Personality, and Successful Aging: Toward a Comprehensive Developmental Model in Later Life

Cited by 40 publications

References 35 publications

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene

Association between home and school food environments and dietary patterns among 9–11-year-old children in 12 countries

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