Genes means pancreatitis

Sonographic features of agenesis of dorsal pancreas

“…The role of genes in the pathogenesis of pancreatitis is being increasingly recognized. [14] The development of diabetes may be due to the absence of the islet cells which usually reside in the body and tail of the pancreas. [3] This, however, is yet to be established.…”

Early events in acute pancreatitis

“…Subsequent controlled studies performed in animal models that simulate the human disease have demonstrated that the acinar cell is the initial site of morphological damage [17]. This conclusion has been supported by genetic studies in patients with a hereditary form of pancreatitis that is linked to mutations in the trypsinogen gene [18,19]. Therefore, it is accepted widely that pancreatitis begins in exocrine acinar cells, and not in the pancreatic ducts, peripancreatic fat tissue, or the interstitium.…”

“…Because trypsin is one of the oldest known digestive enzymes, and because trypsin can activate several other digestive proteases in the gut and in vitro, and because pancreatitis is regarded as a disease caused by proteolytic autodigestion of the pancreas, it would seem reasonable to assume that pancreatitis is caused by a trypsindependent protease cascade within the pancreas itself. If this hypothesis was correct, the trypsinogen mutations that are found in association with hereditary pancreatitis should confer a gain of enzymatic function [18,19], and mutant trypsinogen would be activated more readily inside acinar cells or, alternatively, active trypsin would be degraded less rapidly inside acinar cells. Both events would lead to a prolonged or increased enzymatic action of trypsin within the cellular environment.…”