Genes Polymorphism of Innate Immunity in Children With Neonatal Sepsis

Aim: To clarify the role of polymorphisms rs4986790 and rs4986791 in TLR-4 with susceptibility to neonatal sepsis. Methods: To evaluate the possible correlation of polymorphisms rs4986790 and rs4986791 with sepsis risk, odds ratios (ORs) were calculated. The heterogeneity was evaluated by χ2-based Q-test. Results: For rs4986790, ORs were 1.36 (95% CI: 1.05–1.79, p = 0.017) and 1.84 (95% CI: 0.04–7.9, p = 0.410) under AG+GG versus AA and G vs. A models, respectively. For rs4986791, ORs were 2.22 (95% CI: 1.25–3.94, p = 0.006) and 2.20 (95% CI: 1.26–3.85, p = 0.005) under CT+TT versus CC and of T versus C models, respectively. Conclusion: The rs4986790 and rs4986791 polymorphisms in TLR-4 could influence the sepsis susceptibility in neonates.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Genes Polymorphism of Innate Immunity in Children With Neonatal Sepsis

Cited by 2 publications

References 0 publications

Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis

Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis

Effect of TLR-4 Gene Polymorphisms on Sepsis Susceptibility in Neonates: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About