A clastic dyke has been recognised within manganese (Mn)-rich Cenozoic sediments near a historical Mn-ore deposit in the Miguel Burnier district, Quadrilátero Ferrífero, in the southern São Francisco craton, Brazil. Here, we describe the clastic dyke, a subvertical fissure that is filled with friable arenaceous fragments, and characterise it as seismite. An overprint by stockwork-like Mn-oxide veinlets and Mn-oxide dissemination, mineralogically expressed as birnessite, lithiophorite and jianshuiite, and geochemically represented by metalliferous enrichments, particularly mercury (Hg), occurs in the clastic dyke and its immediate vicinity. Such an overprint also contains illite, which forms a mineral association with birnessite, lithiophorite and jianshuiite, and constrains the temperature of hydrothermal alteration to less than 300 °C. The recognition of seismite and its Hg enrichment indicate that the Cenozoic history of the Quadrilátero Ferrífero cratonic terrane has been affected by seismic episodes, which were not only conducive to local enrichment in Mn at Miguel Burnier, but also to recent seismic-related phenomena such as a dam failure (Agurto-Detzel et al. in GRL 43: 4929–4936, 2016).