Stratabound Zn-Pb-Ba orebodies are hosted in the Lower Cambrian carbonates and Ordovician lithol-ogies of SW Sardinia (Italy). Two groups of genetically distinct ore types are known in the Cambrian: (1) synge-netic(?)-early diagenetic massive sulphides consisting of pyrite>>sphalerite>>galena and barite layers in tidal dolomites, interpreted so far as SedEx-type ores; (2) late-diagenetic replacement and breccia-hosted ore bodies in shallow water limestone with a higher Pb/Zn ratio and a sphalerite>galena>>pyrite association, which have been classically interpreted as MVT ores, but could be easily classified as Irish-type deposits. At the regional scale, most economically significant deposits in SW Sardinia were primarily located along long-living synsedimentary faults. Ordovician stratabound ores, consisting of barite>galena>>sphalerite, were economically less significant than the Cambrian mineralizations. The SW Sardinia ores, together with their host rocks, have been affected by Variscan tectonics, which produced two folding phases, characterized by sub-vertical axial planes-oriented E-W and N-S, and associated inverse faults. A pervasive cleavage, locally overprinting the sedimentary bedding, associated with the N-S-striking folds, strongly deformed the limestone-hosted mineralization, locally increasing the original thickness of the orebodies. During the emplacement of the Variscan granites, contact metamorphism and metasomatism modified both the original mineralogy and the chemical composition of the stratabound ores (e.g., adding Cu, F, As). The late-Variscan deposits consist of skarn bodies around the intrusions or along fault zones, and of high-temperature (HT) vein systems developed along regional tectonic lineaments. From Permian onwards, SW Sardinia experienced several hydrothermal phases, comparable with those occurring in other European terranes. The associated ores consist of low-temperature (LT) veins and palaeokarst breccia fillings in the Cambrian limestone, containing mainly Ag-galena and barite mineralization.