Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring

Hanlon, Margaret A.; Gulati, Ruhi; Johnston, Michael; Fleifil, Yasmeen; Rivas, Maria; Timchenko, Nikolai A.

doi:10.1016/j.jcmgh.2023.11.006

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…In a genetically engineered mouse model of maternal high-fat diet during pregnancy, disruption of the C/EBPα and histone acetyltransferase p300 interaction by substituting serine with alanine at residue 193 on C/EBPα prevents pups from developing NAFLD compared to wildtype mouse pups. Accordingly, the C/EBPα/p300 complex-induced expression of genes involved in NAFLD progression is blocked in mutant mouse pups [89]. In nonhuman primates, Suter et al demonstrated that alterations in fetal acetylation of histone H3 (H3K14ac) were associated with maternal high-fat diet-induced NAFLD in offspring.…”

Section: Microrna and Histone Modificationsmentioning

confidence: 99%

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Tzeng,

Lee

2024

Nutrients

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Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent pediatric liver disorder, primarily attributed to dietary shifts in recent years. NAFLD is characterized by the accumulation of lipid species in hepatocytes, leading to liver inflammation that can progress to steatohepatitis, fibrosis, and cirrhosis. Risk factors contributing to NAFLD encompass genetic variations and metabolic disorders such as obesity, diabetes, and insulin resistance. Moreover, transgenerational influences, resulting in an imbalance of gut microbial composition, epigenetic modifications, and dysregulated hepatic immune responses in offspring, play a pivotal role in pediatric NAFLD development. Maternal nutrition shapes the profile of microbiota-derived metabolites in offspring, exerting significant influence on immune system regulation and the development of metabolic syndrome in offspring. In this review, we summarize recent evidence elucidating the intricate interplay between gut microbiota, epigenetics, and immunity in fetuses exposed to maternal nutrition, and its impact on the onset of NAFLD in offspring. Furthermore, potential therapeutic strategies targeting this network are also discussed.

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Section: Microrna and Histone Modificationsmentioning

confidence: 99%

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Tzeng,

Lee

2024

Nutrients

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New Insights About Epigenetic Mechanisms That Influence Risk of Transgenerational Fatty Liver Disease

Rudnick

2024

Cellular and Molecular Gastroenterology and Hepatology

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Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring

Cited by 2 publications

References 34 publications

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

New Insights About Epigenetic Mechanisms That Influence Risk of Transgenerational Fatty Liver Disease

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