The review aimed to review about the benefit of genetic adaptation of farm animals. Gene helps the farm animals to adapt conditions and able to survive in order to supply food sustainably for the fastest growing global human population. Furthermore, farm animal's genetic adaptation plays a great role to cope up climate change, environmental stresses including extreme hot and cold, disease and parasite and to overcome welfare problems. Accordingly, considering different factors, climatic condition, topography, breed type, relationship with human, disease and parasite resistance, welfare issue, physiological and behavioral status, nutritional habit in harsh environment and management influences, local and cross breeds are more important than exotic breeds to establish an international sustainable farm animal breeding program at farm and laboratory level. Likewise, in-situ and ex-situ adaptive local gene conservation bank should be done properly, especially, in developing countries where their experience is inadequate and local species record at regional level must be realized. Therefore, the importance of this review is unquestionable and must be documented.