Genetic admixture and cardiovascular disease risk in postmenopausal Hispanic women

Zuercher, Monica D; Harvey, Danielle; Au, Lauren E.; Shadyab, Aladdin H.; Nassir, Rami; Robbins, John A.; Seldin, Michael F.; Garcı́a, Lorena

doi:10.1016/j.ijcard.2022.08.020

Cited by 2 publications

(1 citation statement)

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“…Coronary heart disease (CHD), also known as coronary atherosclerotic heart disease, is primarily a heart condition caused by lumen stenosis or blockage due to coronary atherosclerotic lesions, leading to myocardial necrosis, hypoxia, or ischemia. 1 , 2 After women enter menopause, the levels of serum estrogen, such as estradiol decreases, the cardiovascular protective effect of estrogen is lacking, and ventricular remodeling worsens and cardiac function decreases, resulting in a nearly 4-fold increase in the incidence of CHD compared with premenopausal women. 3 Epidemiological investigations have found that the incidence of CHD in premenopausal women was only 1/10-3/10 of that in men, but the incidence and mortality of CHD in perimenopausal and postmenopausal women were significantly increased.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients

2024

Anatol J Cardiol

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Section: Introductionmentioning

confidence: 99%

Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients

2024

Anatol J Cardiol

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Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative

Beydoun,

Kinney

et al. 2024

JAHA

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Background Cardiovascular disease (CVD) remains a leading cause of death for women in the United States, with veterans being at potentially higher risk than their nonveteran counterparts due to accelerated aging and distinct biopsychosocial mechanisms. We examined pathways between selected indicators of socioeconomic status (SES) such as education, occupation, household income, and neighborhood SES and major CVD events through lifestyle and health characteristics among veteran and nonveteran postmenopausal women. Methods and Results A total of 121 286 study‐eligible WHI (Women's Health Initiative) participants (3091 veterans and 118 195 nonveterans) were prospectively followed for an average of 17 years, during which 16 108 major CVD events were documented. Using generalized structural equations modeling coupled with survival analysis techniques, we estimated the effects of SES on major CVD events through smoking, body mass index, comorbidities, cardiometabolic risk factors, and self‐rated health, controlling for WHI component, region, age, race, ethnicity, marital status, and health care provider access. Among veterans, SES characteristics were indirectly related to major CVD events through body mass index, comorbidities, cardiometabolic risk factors, and self‐rated health. Among nonveterans, lower education (β= 0.2, P <0.0001), household income (β=+0.4, P <0.0001), and neighborhood SES (β=+0.2, P <0.0001) were positively related to major CVD events, and these relationships were partly mediated by body mass index, comorbidities, cardiometabolic risk factors, and self‐rated health. Smoking played a mediating role only among nonveterans. Conclusions Nonveteran postmenopausal women exhibit more complex pathways between SES and major CVD events than their veteran counterparts, informing the design, conduct, and evaluation of preventive strategies targeting CVD by veteran status.

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Genetic admixture and cardiovascular disease risk in postmenopausal Hispanic women

Cited by 2 publications

References 35 publications

Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients

Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients

Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative

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