Principal Component Analysis, a statistical tool allowing to create a low dimensional subspace basing on input data, finds many applications in biomechanics. The PCA requires the same topology (mesh connectivity, number of nodes) for all objects in database. To achieve this, each new object added to database must be registered. In this article the finishing registration procedure, based on own software and created especially for biological data sets, is presented. The study of registration process for 3D input data (faces and hands) for PCA is discussed.