1994
DOI: 10.1049/el:19940887
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Genetic algorithm for MCM partitioning

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Cited by 17 publications
(2 citation statements)
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“…[15][16][17][18][19][20][21] In addition, although temperature can be used as a trigger for drug release from nanovesicles due to the elevated temperature in tumor microenvironments because of the high rate of tumor metabolism, 22 imbuing liposomes with precise temperature sensitivity in biologically relevant ranges can be difficult due to the complex nature of their formulations, 23,24 as well as controlling their size to promote predictable ensemble behavior can be challenging due to liposome propensity for wide size distributions upon self-assembly. 25 Therefore, the development of polymersomes that are mechanically robust, have efficient drug loading capacity, and can intelligently respond to environmental stimuli such as temperature or pH, has become of great importance. [26][27][28][29][30] Thus, pH-responsive polymer vesicles made from block copolymers of polybutadiene-b-poly(L-glutamic acid) and polyethyloxide-b-polycaprolactam have been shown to release their cargo through the vesicle disassembly because of degradable bonds within block copolymer structure.…”
Section: Introductionmentioning
confidence: 99%
“…[15][16][17][18][19][20][21] In addition, although temperature can be used as a trigger for drug release from nanovesicles due to the elevated temperature in tumor microenvironments because of the high rate of tumor metabolism, 22 imbuing liposomes with precise temperature sensitivity in biologically relevant ranges can be difficult due to the complex nature of their formulations, 23,24 as well as controlling their size to promote predictable ensemble behavior can be challenging due to liposome propensity for wide size distributions upon self-assembly. 25 Therefore, the development of polymersomes that are mechanically robust, have efficient drug loading capacity, and can intelligently respond to environmental stimuli such as temperature or pH, has become of great importance. [26][27][28][29][30] Thus, pH-responsive polymer vesicles made from block copolymers of polybutadiene-b-poly(L-glutamic acid) and polyethyloxide-b-polycaprolactam have been shown to release their cargo through the vesicle disassembly because of degradable bonds within block copolymer structure.…”
Section: Introductionmentioning
confidence: 99%
“…In EGAAM an elitist selection mechanism [34][35][36] was employed. In elitist selection, M s = MP s strings with the best fitness enter the new population unchanged, while M c = MP c strings are produced by crossover between the parent strings.…”
Section: Selection and Reproductionmentioning
confidence: 99%