The study explore machine learning techniques to predict temperature-dependent photoluminescence spectra in colloidal CdSe nanoplatelets, leveraging polynomial regression models trained on experimental data from 85 to 270 K spanning temperatures to forecast photoluminescence spectra backward to 0 K and forward to 300 K. 6th-degree polynomial models with Tweedie regression were optimal for band energy B1 predictions up to 300 K, while 9th-degree models with LassoLars and Linear Regression regressors were suitable for backward predictions to 0 K. For exciton energy B2, the Lasso model of degree 5 and the Ridge model of degree 4 performed well up to 300 K, while the Tweedie model of degree 2 and Theil-Sen model of degree 2 showed promise for predictions to 0 K. Furthermore, we utilize a GA-based approach to fit experimental data to theoretical model of Fan and Varshni equations, facilitating a comparative analysis with the ML-predicted curves.