Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat

Diabetes-Associated Complications in Spontaneously Diabetic Torii Fatty Rats

“…Body weight, food intake, biochemical parameters, and renal parameters were evaluated at 4,6,8,16,24, and 32 weeks of age. Blood samples were collected from the tail vein of rats.…”

“…ERGs were obtained at 6,8,16,24, and 32 weeks of age using the method of Segawa et al [18], with minor modification. Rats adapted to darkness for at least 60 min, then anaesthetized with an intraperitoneal injection of 50 mg/kg ketamine (Sankyo, Tokyo, Japan).…”

“…The SDT normal rat develops diabetes from about 20 weeks of age [8,20]. It is worthy of note that the SDT normal rat shows ocular complications such as venous dilation and meandering vascular networks, which are caused by hyperglycemia [16].…”

Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice

“…Quantitative trait loci (QTL) analysis has been applied to several rodent models of T2D to identify chromosomal loci for genetic modifiers. QTL analysis of obese animal models of T2D such as the OLETF rat (Kim et al 1998), the KKA y mouse (Suto et al 1998a, b), the NZO mouse (Reifsnyder et al 2000; Taylor et al 2001), and the TSOD mouse (Hirayama et al 1999), as well as nonobese animal T2D models such as the GK rat (Galli et al 1996; Gauguier et al 1996) and the SDT rat (Masuyama et al 2003), have identified QTLs that influence factors such as plasma glucose and insulin concentrations, body weight (BW), and fat weight. While a number of genes have been implicated in monogenic etiologies for T2D from animal models of diabetes, including ob, db, Tub, A y , and Agrp, none of these genes appears to explain the genetic background of most T2D cases in humans.…”

Pancreatic Function of Spontaneously Diabetic Torii Rats in Pre-Diabetic Stage

“…Masuyama et al performed quantitative trait locus (QTL) analysis of the SDT rat and clarified that three loci, Gisdt1 (Glucose intolerance in SDT rat 1), Gisdt2, and Gisdt3, are involved in glucose intolerance on chromosomes 1, 2, and X, respectively [10]. Since these traits of exacerbated glucose tolerance are attributed to polygenic effects, an analysis of SDT rats would be highly useful in studies of the relationship between diabetes-associated genes and diabetes mellitus.…”