Genetic Analysis for Insulitis in NOD Mice

Makino, Susumu; Muraoka, Yuki; Kishimoto, Yoshio; Hayashi, Yoshiyuki

doi:10.1538/expanim1978.34.4_425

Cited by 51 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the fact that NOD athymic mice displayed no insulitis provides definite evidence that T lymphocytes are essential for the development of insulitis in NOD mice. In addition, NOD athymic mice showed the absence of overt diabetes, which strongly supports our hypothesis that insulitis is the primary change leading to the development of diabetes in NOD mice [10,12].…”

supporting

confidence: 87%

“…Again, there was no difference in the incidences of lymphocytic infiltration in each organ between NOD euthymic and NOD mice of either sex. These findings mean that the two recessive genes controlling the development of insulitis [12] had been completely transferred to mice of the N4 F1 generation regardless of the presence or absence of the thymus. Therefore, the fact that NOD athymic mice displayed no insulitis provides definite evidence that T lymphocytes are essential for the development of insulitis in NOD mice.…”

mentioning

confidence: 88%

“…Recently, based on breeding experiments between NOD and C57 BL/6J mice, we found that two recessive genes located on independent autosomal chromosomes are necessary for the development of insulitis in NOD mice [12].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Makino

Harada

Kishimoto

et al. 1986

Experimental Animals

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 87%

mentioning

confidence: 88%

See 1 more Smart Citation

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Makino

Harada

Kishimoto

et al. 1986

Experimental Animals

Self Cite

View full text Add to dashboard Cite

“…The susceptibility to IDDM has been shown to be associated with certain alleles of the major histocompatibility complex (MHC) class II genes, HLA-DQAI and HLA-DQBI (3)(4)(5)(6)(7). The nonobese diabetic (NOD) mouse spontaneously develops IDDM with remarkable similarities to the human disorder (8,9). Experimental crosses between NOD and other strains of mice revealed that there are several susceptibility genes necessary for disease onset in NOD mice (10)(11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules.

Miyazaki

Matsuda

Toyonaga

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Inbred colonies of NOD (nonobese diabetic) mice have The NOD and related inbred strains were developed at become widely established around the world since the the Shionogi Research Laboratories in Aburahi, Japan, publication of the initial report (Makino et al, 1980) by Dr. S. Makino (Makino et al, 1980(Makino et al, , 1985. A combidescribing this strain's susceptibility to spontaneous denation of inbreeding and selective breeding began in 1966 velopment of autoimmune (type 1) insulin-dependent diabetes with progeny from an outbred Jc:ICR female mouse that mellitus (IDDM).…”

Section: Introduction Development Of the Nod Strainmentioning

confidence: 99%

Institute of Laboratory Animal Resources (ILAR)

Wolfle¹

1994

View full text Add to dashboard Cite

DTIe QUALITY INSPECTED 8 7 28 050Foirn Approved REPORT DOCUMENTATION PAGE OMB No. 0704-0188Pubic r 'oOrlno burden tot In,% cc(. tcCt information is ettmat d to aretaCe I hourer reipor.e Includintg the time for reviewing instructions. searching existing data ources. gatherian and mantaining te caa neecei, and ccrnoletinq and reviewing the' "cliecCn Of intOma :Ol Sena COMMtet lie re*1r 6n thli burden estfrte f any other aset Of this Approved for public release; distribution unlimited ABSTRACT (Maximum 200 words)This grant provides partial core support for the Institute of Laboratory Animal Rqsources (ILAR), which is a component of the Commission on Life Sciences (CLS), one of the principal operating units of the National Academy of Sciences (Academy). The Academy operates as a private, non-profit institution charged with providing advice to agencies of the federal government on matters of science and technology. ILAR provides information on the selection, care, and use of biologicals and animals used in research, testing, and education. ILAR's best known report is the Guide for the Care and Use of Labora..orv Animals (Guide), of which the 6th revision was initiated during this grant year. Oversight for the work of ILAR is provided by ILAR Council, a standing committee of 13 scientists, veterinarians, and ethicists, which meets three times each year to review all aspects of ILAR's program and develop new initiatives. ILAR has two types of programs:core and special projects. This grant supports the core program, consisting of the meetings and activities of Council and those of staff in the publishing of ILAR News, in the activities of the Animal Models and Genetic Stocks Information Program, and International Activities. SUBJECT TERMS 1S. NUMBER OF PAGESlaboratory animal care and use, animal research, international 12 activities, collection and importation of biologic materials, 16 PRICE CODE biologic databases, ILAR News, animal models and genetic stocks. Where copyrighted material is quoted, permission has been obtained to use such material.Where material from documents designated for limited distribution is quoted, permission has been obtained to use the material.Citations of coImercial organizations and trade names in this report do not constitute an official Department of Army endorsement or approval of the products or services of these organizations.In conducting research using animals, the investigator(s) adhered to the "Guide for the Care and Use of Laboratory For the protection of human subjects, the investigator(s) adhered to policies of applicable Federal Law 45 CFR 46.In conducting research utilizing recombinant DNA technology, the investigator(s) adhered to current guidelines promulgated by the National Institutes of Health.In the conduct of research utilizing recombinant DNA, the investigator(s) adhered to the NIB Guidelines for Research Involving Recombinant DNA Molecules.In the conduct of research involving hazardous organisms, the investigator(s) adhered to the CDC-NIH Guide for Biosafety in Microbi...

show abstract

Genetic Analysis for Insulitis in NOD Mice

Cited by 51 publications

References 25 publications

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules.

Institute of Laboratory Animal Resources (ILAR)

Contact Info

Product

Resources

About