Genetic Analysis of a Family with Multiple Incidences of Prostate Cancer

Abstract

A family with multiple members diagnosed with prostate cancer was identified, and genetic variants were analyzed. Three brothers were diagnosed with prostate cancer. Germline variants in <i>BRCA1</i>, <i>BRCA2</i>, <i>TINF2</i>, and <i>CD19</i> were found through next-generation DNA sequencing using a hereditary cancer panel. The <i>BRCA1</i> G275D variant was present in patients, but absent in the healthy member. An <i>ELAC2</i> variant was found in 1 patient. Several mutations were predicted to be deleterious by a set of computation programs. Multiple gene mutations might contribute to the overall predisposition to prostate cancer in the family. Even in cases with potentially deleterious variants in <i>BRCA1</i> or <i>BRCA2</i>, there could be diverse clinical manifestations.