Genetic Analysis of a Novel Pathway for
            <scp>d</scp>
            -Xylose Metabolism in
            <i>Caulobacter crescentus</i>

Stephens, Craig; Christen, Beat; Fuchs, Thomas; Sundaram, Vidyodhaya; Watanabe, Kelly; Jenal, Urs

doi:10.1128/jb.01438-06

Cited by 169 publications

(155 citation statements)

References 31 publications

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“…crescentus and Azo. brasilense, employing the same first steps in pentose degradation, belong to the SDR and the GFO/ IDH/MocA families, respectively (285,351).…”

Section: Pentose Oxidation and Xylose Dehydrogenase/arabinose Dehydromentioning

confidence: 99%

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Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

Bräsen

Esser

Rauch

et al. 2014

Microbiol Mol Biol Rev

279

294

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SUMMARY The metabolism of Archaea , the third domain of life, resembles in its complexity those of Bacteria and lower Eukarya . However, this metabolic complexity in Archaea is accompanied by the absence of many “classical” pathways, particularly in central carbohydrate metabolism. Instead, Archaea are characterized by the presence of unique, modified variants of classical pathways such as the Embden-Meyerhof-Parnas (EMP) pathway and the Entner-Doudoroff (ED) pathway. The pentose phosphate pathway is only partly present (if at all), and pentose degradation also significantly differs from that known for bacterial model organisms. These modifications are accompanied by the invention of “new,” unusual enzymes which cause fundamental consequences for the underlying regulatory principles, and classical allosteric regulation sites well established in Bacteria and Eukarya are lost. The aim of this review is to present the current understanding of central carbohydrate metabolic pathways and their regulation in Archaea . In order to give an overview of their complexity, pathway modifications are discussed with respect to unusual archaeal biocatalysts, their structural and mechanistic characteristics, and their regulatory properties in comparison to their classic counterparts from Bacteria and Eukarya . Furthermore, an overview focusing on hexose metabolic, i.e., glycolytic as well as gluconeogenic, pathways identified in archaeal model organisms is given. Their energy gain is discussed, and new insights into different levels of regulation that have been observed so far, including the transcript and protein levels (e.g., gene regulation, known transcription regulators, and posttranslational modification via reversible protein phosphorylation), are presented.

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“…crescentus and Azo. brasilense, employing the same first steps in pentose degradation, belong to the SDR and the GFO/ IDH/MocA families, respectively (285,351).…”

Section: Pentose Oxidation and Xylose Dehydrogenase/arabinose Dehydromentioning

confidence: 99%

“…solfataricus genome. The recently crystallized gluconolactonase from Xanthomonas campestris as well as the xylonolactonases/arabinolactonases from Azospirillum brasilense and Caulobacter crescentus belong to the same superfamily of SMP-30 proteins (284)(285)(286). In Hfx.…”

Section: Bacteria Eukaryamentioning

confidence: 99%

Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

Bräsen

Esser

Rauch

et al. 2014

Microbiol Mol Biol Rev

279

294

View full text Add to dashboard Cite

show abstract

“…Microarray analysis demonstrates that growth on xylose, a component of the plant cell wall polymer xylan, also induces transcription of genes that are predicted to encode proteins used to metabolize other xylan components, indicating a robust regulon (88). Additionally, xylose metabolism is used as a genetic tool with ectopic expression of proteins controlled by the xylX promoter, but this tool is feasible only because C. crescentus does not display catabolite repression (161,238,247). C. crescentus also utilizes a PAS-kinase molecular oxygen sensing-signaling system (42).…”

Section: Metabolic Input Into Developmentmentioning

confidence: 99%

Getting in the Loop: Regulation of Development inCaulobacter crescentus

Curtis

Brun

2010

Microbiol Mol Biol Rev

244

233

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SUMMARY Caulobacter crescentus is an aquatic Gram-negative alphaproteobacterium that undergoes multiple changes in cell shape, organelle production, subcellular distribution of proteins, and intracellular signaling throughout its life cycle. Over 40 years of research has been dedicated to this organism and its developmental life cycles. Here we review a portion of many developmental processes, with particular emphasis on how multiple processes are integrated and coordinated both spatially and temporally. While much has been discovered about Caulobacter crescentus development, areas of potential future research are also highlighted.

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“…In metabolic pathways that require lactone hydrolysis, a lactonase is often employed to facilitate the reaction (5,10,30,31). Although the salinosporamide gene cluster does not contain a lactonase, a search of the total genome sequence of S. tropica CNB-440 (32) resulted in one annotated gluconolactonase.…”

Section: Metal Dependence and Lactonasementioning

confidence: 99%

“…Potentially related pentose 1-dehydrogenases such as Larabinose 1-dehydrogenase and D-xylose 1-dehydrogenase have been shown to oxidize a cyclical hemiacetal substrate to the corresponding lactone (5,6,9,10). Glucose 1-dehydrogenase has also been reported to possess "gluconolactonase" activity, catalyzing both the oxidation of glucose to gluconolactone and the subsequent hydrolysis to gluconate (6).…”

mentioning

confidence: 99%

Characterization of 5-Chloro-5-Deoxy-d-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis

Kale

McGlinchey

Moore

2010

Journal of Biological Chemistry

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SalM is a short-chain dehydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the biosynthesis of chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhibitor salinosporamide A. SalM was heterologously overexpressed in Escherichia coli and characterized in vitro for its substrate specificity, kinetics, and reaction profile. A sensitive real-time 13

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Genetic Analysis of a Novel Pathway for d -Xylose Metabolism in Caulobacter crescentus

Cited by 169 publications

References 31 publications

Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

Getting in the Loop: Regulation of Development inCaulobacter crescentus

Characterization of 5-Chloro-5-Deoxy-d-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis

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