Genetic analysis of bipolar disorder: Summary of GAW10

Rice, John P.

doi:10.1002/(sici)1098-2272(1997)14:6<549::aid-gepi1>3.0.co;2-v

Cited by 17 publications

(9 citation statements)

References 10 publications

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“…It has been proposed that a locus for BD can be assigned to chromosome 18 based on positive linkage results found by independent studies [Berrettini et al, 1997]. There remains, however, some controversy over this issue [Rice, 1997]. Though much has been thought about interpreting linkage results in complex traits such as psychiatric disorders, it is still not clear, in practice, when linkage should be considered replicated.…”

Section: Discussionmentioning

confidence: 99%

Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study

et al. 1999

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Over the last three years several studies have investigated the hypothesis of linkage between bipolar disorder and markers on chromosome 18. Although independent groups have reported positive results, it is still not clear how these should be interpreted, as linkage spans a considerably large segment of the chromosome. In this study we have investigated linkage with chromosome 18 markers in 19 families of lithium-responsive bipolar patients, as a way to select a more homogeneous population. In addition, we have investigated whether there is evidence of a parent-of-origin effect as suggested by previous studies. Eleven markers spanning the whole chromosome were typed and linkage analysis was carried out using parametric and nonparametric methods. Analysis of the whole sample provided nonsignificant linkage results. However, when the sample included only unilineal families, and was further stratified according to parental origin, two chromosomal regions provided modestly positive lod scores. Maximum lod scores of 1.04 (P = 0.001) at D18S53 and 0.87 (P = 0.045) at D18S61 were observed for maternal and paternal pedigrees, respectively. Nonparametric analysis yielded similar results. In conclusion, our results are congruent with previous reports that suggest an advantage of unilineal pedigrees in linkage analysis of bipolar disorder and cannot rule out a parent-of-origin effect in this genomic region.

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Section: Discussionmentioning

confidence: 99%

Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study

et al. 1999

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“…Each of these data sets provided statistical evidence reaching the suggestive level but not the level recommended (see Lander and Kruglyak 1995) as being statistically significant. A metanalysis was performed on the three data sets noted above and on two others (Knowles et al 1998;Rice 1997). The genotypes and phenotypes of the 382 affected sib pairs in the 185 kindreds analyzed (Lin and Bale 1997) supported linkage, with statistical significance ( ).…”

Section: Introductionmentioning

confidence: 99%

Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

Friddle

Koskela

Ranade

et al. 2000

The American Journal of Human Genetics

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A genome scan of approximately 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

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“…Parent-of-origin effect has been investigated in several combined studies of linkage data on chromosome 18 in BPAD from several centers in North America (including the above) and in Europe (Rice 1997). Linkage results varied widely depending on selection of datasets, statistical approaches used for meta-analysis, linkage parameters, and phenotypic definition of the disease (Collins and Go 1997, Donald et al 1997, Greenwood and Bull 1997, Lin and Bale 1997, with the overall conclusion that parent-of-origin effect cannot be excluded for chromosome 18p and 18q markers in BPAD.…”

Section: Chromosome 18 and Bipolar Affective Disordermentioning

confidence: 98%

The Genes for Major Psychosis Aberrant Sequence or Regulation?

Petronis

2000

Neuropsychopharmacology

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Genetic analysis of bipolar disorder: Summary of GAW10

Cited by 17 publications

References 10 publications

Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study

Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study

Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

The Genes for Major Psychosis Aberrant Sequence or Regulation?

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