Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: Fatty acid binding protein-7 (brain type)

Wagner, Amy J.; Stumbaugh, Amber; Tigue, Zachary; Edmondson, Jess; Paquet, Agnès; Farmer, Diana L.; Hawgood, Samuel

doi:10.1016/j.jamcollsurg.2007.06.090

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FABP7, which is involved in brain and breast development, has been discovered in human lung specimens. There is decreased expression of FABP7 in fetal lungs with CPAM, suggesting a potential role in pulmonary development [17]. Finally, FABP4 has been detected in endothelial cells of both human placental vessels and infantile hemangiomas, with knockdown of FABP4 significantly reducing endothelial cell proliferation [18].…”

Section: Discussionmentioning

confidence: 99%

Familial case of prenatally diagnosed intralobar and extralobar sequestrations with cystadenomatoid change

Klein

Turner

Dobson

et al. 2011

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Familial case of prenatally diagnosed intralobar and extralobar sequestrations with cystadenomatoid change

Klein

Turner

Dobson

et al. 2011

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…In fact, histologically, the tissue excised from the child being reported and the histological illustrations published in similar cases [6][7][8]11,13,14,16] bear a great resemblance to the pulmonary congenital cystic adenomatoid malformation. In that respect, it is interesting to note that in the case of the congenital cystic adenomatoid malformation, a genetic element, the fatty acid binding protein-7 seems to be involved, indicating an aberration in the signaling pathway during lung development [23]. It also happens that fatty acid binding protein-7 is involved in breast development as well [24], at least in transgenic mice, and one may wonder whether it plays a role in the pathogenesis of the infantile galactocele, the genetic aspect of which has not yet been explored.…”

Section: Discussionmentioning

confidence: 99%

The Galactocele of Male Infants: An Intriguing Entity. Study and Reflection about a Case, with Review of the Literature

et al. 2011

View full text Add to dashboard Cite

In this report, the authors investigate and discuss a galactocele that developed in the breast of a 5-month-old male. Based on the histological and immunohistochemical findings, they suggest that the rare and intriguing process that is exclusively observed in males in the absence of any detectable hormonal stimulation at time of investigation could represent a developmental anomaly possibly promoted by an obstructive phenomenon involving a defect of hollowing of some primary epidermal buds, the precursors of the mammary ducts.

show abstract

“…The disease is characterized by proliferation of pseudoglandular bronchial structures, formation of multiple cysts in the terminal bronchioles, and lack of alveolar development 4 . Stocker classification of CPAM includes five subtypes: type 0, lesions are composed of bronchial‐like tissue; type I, single or multiple large cysts (>2 cm in diameter); type II, multiple small cysts (<1 cm in diameter); type III, solid and microcystic lesions; and type IV, lesions of more distal acinar origin 5 . The condition does not regress after birth, and the development of fetal hydrops is associated with an increased risk of death 6 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Wnt7B and BMP4 expression patterns in congenital pulmonary airway malformation

Zhu

Liú

Jia

2020

Pediatric Pulmonology

View full text Add to dashboard Cite

Background Congenital pulmonary airway malformation (CPAM) is a rare disorder characterized by aberrant overgrowth of terminal bronchioles. The objective of this study was to describe wingless‐type MMTV integration site family 7B (Wnt7B) and bone morphogenetic protein 4 (BMP4) expression patterns in human CPAM lesions and to explore the possible roles of Wnt7B and BMP4 in the pathogenesis of CPAM. Methods Fifteen tissue samples from patients with CPAM were obtained from the Pathology Department of Shengjing Hospital of China Medical University. Samples representing CPAM lesions and adjacent normal lung tissues were collected and Wnt7B and BMP4 expression was detected through immunohistochemical (IHC) staining, quantitative real‐time polymerase chain reaction (qRT‐PCR), and Western blotting. Results IHC revealed that Wnt7B immunopositive cells were only detected in epithelial cells, whereas BMP4 immunopositive cells were detected in epithelial and mesenchymal cells. Expression of Wnt7B and BMP4 immunopositive cells was higher in CPAM lesions than that in adjacent normal lung tissue. qRT‐PCR and Western blotting showed that Wnt7B and BMP4 mRNA and protein expression were significantly higher in CPAM lesions than in adjacent normal lung tissue (P < .05). Overall, the level of BMP4 was higher than that of Wnt7B. Conclusions Increased expression of Wnt7B and BMP4 appear to be related to the pathogenesis of CPAM and abnormal pulmonary development. Upregulation of Wnt7B and BMP4 could play an important role in the development of the bronchial‐alveolar structures that characterize CPAM.

show abstract

Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: Fatty acid binding protein-7 (brain type)

Cited by 3 publications

References 0 publications

Familial case of prenatally diagnosed intralobar and extralobar sequestrations with cystadenomatoid change

Familial case of prenatally diagnosed intralobar and extralobar sequestrations with cystadenomatoid change

The Galactocele of Male Infants: An Intriguing Entity. Study and Reflection about a Case, with Review of the Literature

Analysis of Wnt7B and BMP4 expression patterns in congenital pulmonary airway malformation

Contact Info

Product

Resources

About