Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis

Eiseler, Katharina; Dropmann, Lea Maria; Bugert, Peter; Ewers, Maren; Witt, Heiko

doi:10.1016/j.pan.2022.09.240

Search citation statements

Order By: Relevance

Paper Sections

Select...

Role Of Aqps In Exocrine Pancreatic Secretion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study using Aqp12 knockout mice has suggested AQP12 may participate in the mechanisms that control the exocrine pancreatic secretory function in response to following rapid and intense stimulation [254]. Very recently, the contribution of AQP12 to pancreatic juice secretion has also been revealed in patients presenting a nonsense mutation in the Aqp12B gene, one of the two homologous Aqp12 genes (Aqp12A and Aqp12B) [255]. Overall, additional studies are still necessary to evaluate the specific contribution of each AQP to pancreatic fluid secretion.…”

Section: Role Of Aqps In Exocrine Pancreatic Secretionmentioning

confidence: 99%

Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease

Calamita,

Delporte

2023

Cells

View full text Add to dashboard Cite

Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner’s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion.

show abstract

Section: Role Of Aqps In Exocrine Pancreatic Secretionmentioning

confidence: 99%