Genetic analysis of the TBX1 gene promoter in indirect inguinal hernia

Han, Qingluan; Li, Chunyu; Li, Wei; Fan, Hongjin; Xing, Qining; Yan, Bo

doi:10.1016/j.gene.2013.11.012

Cited by 13 publications

(15 citation statements)

References 45 publications

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“…The remaining protein interactions were employed to construct the inguinal hernia PPI network in which proteins serve as nodes and protein-protein interactions serve as edges. Protein identifiers were unified using the protein IDs defined in the UniProt database [24]. Because some proteins were given multiple names, the results in tables and figures were presented in the format of gene names and UniProt IDs to avoid the ambiguous referring.…”

Section: Inguinal Hernia-related Genes and Construction Of Ppi Networkmentioning

confidence: 99%

“…Additionally, individuals with connective tissue genetic diseases such as cutis laxa [16], Marfan syndrome [17], and Ehlers-Danlos syndrome [18] have a greater risk of developing inguinal hernias. To date, only a small number of those candidate genes have been investigated [19][20][21][22][23][24]. Among those findings, a large genome-wide association study recently identified four novel inguinal hernia susceptibility loci in the regions of EFEMP1, WT1, EBF2, and ADAMTS6.…”

Section: Introductionmentioning

confidence: 99%

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A network analysis revealed the essential and common downstream proteins related to inguinal hernia

Mao

Chen

et al. 2020

PLoS ONE

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Although more than 1 in 4 men develop symptomatic inguinal hernia during their lifetime, the molecular mechanism behind inguinal hernia remains unknown. Here, we explored the protein-protein interaction network built on known inguinal hernia-causative genes to identify essential and common downstream proteins for inguinal hernia formation. We discovered that PIK3R1, PTPN11, TGFBR1, CDC42, SOS1, and KRAS were the most essential inguinal hernia-causative proteins and UBC, GRB2, CTNNB1, HSP90AA1, CBL, PLCG1, and CRK were listed as the most commonly-involved downstream proteins. In addition, the transmembrane receptor protein tyrosine kinase signaling pathway was the most frequently found inguinal hernia-related pathway. Our in silico approach was able to uncover a novel molecular mechanism underlying inguinal hernia formation by identifying inguinal herniarelated essential proteins and potential common downstream proteins of inguinal herniacausative proteins. OPEN ACCESSCitation: Mao Y, Chen L, Li J, Shangguan AJ, Kujawa S, Zhao H (2020) A network analysis revealed the essential and common downstream proteins related to inguinal hernia. PLoS ONE 15 (1): e0226885. https://doi.org/10.

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Section: Inguinal Hernia-related Genes and Construction Of Ppi Networkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A network analysis revealed the essential and common downstream proteins related to inguinal hernia

Mao

Chen

et al. 2020

PLoS ONE

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“…Key words: phytoplasma; promoter; gene structure; genetic diversity; multilocus sequence analysis (Candidatus phytoplasma australiense, PAa) (AM42-2018)和草莓致死黄化植原体(strawberry lethal yellows phytoplasma, SLY) (CP002548), 还有16SrX组的苹果簇生植原体(Ca. P. mali, AT) (CU469464) (Oshima et al, 2004;Bai et al, 2006;Tran-Nguyen et al, 2008;Kube et al, 2008;Andersen et al, 2013 结构 (Post & Nomura, 1980;朱玉贤和李毅, 2002)。大肠杆菌中rpS10基因在str操纵子下游15 kb处, 与核糖体蛋白编码基因rpl3、rpl4等组成S10操纵子, 在S10操纵子3'端发现转录终止结构 (Post & Nomura, 1980;Zurawski & Zurawski, 1985)。Sanange-lantoni等(1993)研究发现甲烷叶菌(Methanococcus vannielii)的核糖体蛋白编码基因rpS10与tuf基因连在一起与str操纵子一起转录。spc操纵子和S10操纵子在大肠杆菌基因组中均有发现 (Post & Nomura, 1980;Zurawski & Zurawski, 1985) (Ishii et al, 2009;Du et al, 2014;Zhang et al, 2014)…”

Section: 研究报告unclassified

Structures of the tuf gene and its upstream part genes and characteristic analysis of conserved regions and activity from related gene promoters of a phytoplasma

Yu¹,

Lin²,

Wang³

et al. 2018

Biodiversity Science

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Studies on the genetic diversity, key gene regulation and control of phytoplasma, which cause many diseases with various host plants and have a wide geographical distribution, will be conducive to facilitating integrated disease control. The large DNA fragments including tuf gene sequences and upstream six genes from PaWB-sdyz, PaWB-fjfz and LY-fjya1 strains were amplified using long fragment PCR primers. Sequence characteristic of conserved regions of the phytoplasma gene promoter and MLSA were performed. Upstream sequences adjoining the tuf gene was recombined with promoter-probe vector pSUPV4 to analyze their promoter activity. The sequences, 12,745-12,748 bp in length, of upstream tuf genes were amplified from the three strains. Comparative analysis showed that the gene structure order of the tuf gene and its upstream six gene sequences of PaWB-sdyz, PaWB-fjfz, LY-fjya1, OY-M, AYWB, PAa, SLY, AT phytoplasma strains were identical in the arrangement of 5'-rplL-rpoB-rpoC-rps12-rps7-fusA-tuf-3'. The potential sequence pattern of conserved region of the phytoplasma promoter was deduced: T 90 T 100 G 92 T 75 G 67 A 85 (-35 region); T 90 A 96 T 92 A 98 T 73 T 90 (-10 region). The different phytoplasma strains were clearly divided with comparatively high bootstrap values based on MLSA of coding genes, non-coding sequences, and deduced amino acid sequences of rplL-tuf nucleotide sequences. Genetic variation was comparatively high in the non-coding nucleotide sequences. A 130-bp upstream sequence of the tuf gene in PaWB-fjfz, LY-fjya1 strains and a

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“…Zhang et al's [7] team have found that the functional sequence variants of some genes may be a risk factor for indirect inguinal hernia, such as gene TBX1, gene TBX3, gene SIRT1, and gene GATA6. These variants may affect the differentiation and proliferation of human skeletal muscles and fibroblasts [7][8][9][10]. …”

Section: Etiologymentioning

confidence: 99%

Individualized Treatment of Inguinal Hernia in Children

Chen¹,

Chu²,

Shen³

et al. 2017

Hernia

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The incidence of inguinal hernias in various age groups of children ranges from 0.8 to 4.4%. Pediatric indirect inguinal hernia is congenital, originating in the patent processus vaginalis. The inguinal hernia repair is one of the most common pediatric operations. The traditional high hernia sac ligation is the primary treatment for younger patients from 1 to 13 years of age and can correct the condition. The authors performed the high ligation of the hernia sac by the laparoscopic approach for the patients under 13 years old and achieved good therapeutic results in the last 10 years. However, through our clinical study, the authors found that the simple high ligation of hernia sac is inadequate for patients from 13 to 18 years of age, who had a longer medical history, larger diameter of the internal inguinal ring, and more serious defects of the transverse fascia. Pediatric inguinal hernias are prone to postoperative recurrence if the patients were only treated with the high ligation of hernia sac. To repair the transverse fascia and strengthen the posterior wall of the inguinal canal, Lichtenstein hernioplasty with a biological patch was performed for the patients from 13 to 18 years in the authors' department. The aims of this chapter are to narrate the individualized treatment of inguinal hernia in children and try to provide relatively reasonable operative methods.

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Genetic analysis of the TBX1 gene promoter in indirect inguinal hernia

Cited by 13 publications

References 45 publications

A network analysis revealed the essential and common downstream proteins related to inguinal hernia

A network analysis revealed the essential and common downstream proteins related to inguinal hernia

Structures of the tuf gene and its upstream part genes and characteristic analysis of conserved regions and activity from related gene promoters of a phytoplasma

Individualized Treatment of Inguinal Hernia in Children

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