Genetic analysis of tumorigenesis: a conserved region in the human and Chinese hamster genomes contains genetically identified tumor-suppressor genes.

Stenman, Göran; Sager, Ruth

doi:10.1073/pnas.84.24.9099

Cited by 25 publications

(11 citation statements)

References 31 publications

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“…There has been much speculation that a tumor suppressor gene or genes are located in a syntenic region near the Hbb locus on human Chr 11p15 [31][32][33][34], mouse Chr 7 [5,35], rat Chr 1 [21], and hamster Chr 3 [20]. In the study reported here, LOH was detected in seven tumors, and in six the longer Hbb allele was preferentially maintained over the shorter allele.…”

Section: Preferential Chromosomal Lossmentioning

confidence: 57%

“…Experimental carcinogenesis in many other species results in Hras1 mutations and associated LOH. In Chinese hamster cells, transfection of mutant Hras1 genes results in LOH on Chr 3, which contains the wild-type Hras1 gene [19,20]. Nmethyl-N-nitrosourea-induced rat mammary tumors have gross chromosomal changes on Chr 1, which is syntenic with human Chr 11 and mouse Chr 7.…”

Section: Introductionmentioning

confidence: 99%

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Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1

Yuan¹,

Hu²,

Lentsch³

et al. 1997

Mol. Carcinog.

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We have previously shown that all CBA/J mice exposed to 4-nitroquinoline-1-oxide (4NQO) eventually develop oral cavity squamous cell carcinomas, and two-thirds of these tumors have Ha-ras-1 (Hras1) point mutations at codon 12. Half of the tumors with Hras1 mutations have loss of heterozygosity (LOH) at Hras1. In the study reported here, seven tumors with LOH at Hras1, six heterozygous for Hras1, and six without Hras1 mutations were analyzed to define the extent of LOH on chromosome (Chr) 7. Microsatellite polymorphisms present in CBA/J mice were used as informative allelic markers. Tumors with LOH at Hras1 showed consistent allelic loss at the distal portion of Chr 7. The boundary of allelic loss lay between the tyrosinase and hemoglobin beta chain loci, which are 6 cM apart. None of the tumors that remained heterozygous for Hras1 or had no Hras1 mutations had evidence of chromosomal loss involving Chr 7. Because LOH was only detected in advanced lesions long after exposure to 4NQO had ceased, we presume that the chromosomal alterations by which LOH occurred were independent of the carcinogen exposure. The development of LOH in only half of the tumors with Hras1 point mutations suggests that LOH was not caused by the initial Hras1 point mutation but was a highly selected event during tumorigenesis.

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Section: Preferential Chromosomal Lossmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1

Yuan¹,

Hu²,

Lentsch³

et al. 1997

Mol. Carcinog.

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“…1983) and hybridized in situ as previously described (H arper and Saunders. 1981;Stenman and Sager. 1987).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13

Stenman

Sahlin

Dumanski³

et al. 1992

Cytogenet Genome Res

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“…The P2 and P3 probes were 3H-labeled by oligonucleotide labeling (Feinberg and Vogelstein. 1983) and hybridized in situ as previously described (Harper andSaunders, 1981: Stenman andSager, 1987). Hybridization was per formed for 16 h at 37 ° C at probe concentrations of 100 ng/ml hybridization solution.…”

Section: ------1-0 -If----------hi-----0-------------------------h -Omentioning

confidence: 99%

The human platelet-derived growth factor α chain (PDGFA) gene maps to chromosome 7p22

Stenman

Rorsman²,

Huebner³

et al. 1992

Cytogenet Genome Res

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Genetic analysis of tumorigenesis: a conserved region in the human and Chinese hamster genomes contains genetically identified tumor-suppressor genes.

Abstract: Regional chromosome homologies were found in a comparison of human lip with Chinese hamster 3p.

Cited by 25 publications

References 31 publications

Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1

Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1

Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13

The human platelet-derived growth factor α chain (PDGFA) gene maps to chromosome 7p22

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