Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000–2001 epidemic

Na, Byoung Kuk; Shin, Ju Mi; Lee, Joo Yeon; Shin, Gu Choul; Kim, Yoon Young; Lee, Jin Soo; Lee, Jong Koo; Cho, Hae Wol; Lee, Hoan Jong; Rota, Paul A.; Bellini, William J.; Kang, Chun

doi:10.1002/jmv.10444

Cited by 15 publications

(10 citation statements)

References 32 publications

(33 reference statements)

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“…The H1 genotype was also detected in large outbreaks in both Japan, and Korea in 2000–2001 [22,23]. Genotypes D3, D5, and D9 were the most frequently detected genotypes in Japan before the outbreaks associated with genotype H1 suggesting that the recent H1 viruses in Japan originated in China.…”

Section: Resultsmentioning

confidence: 99%

Molecular epidemiology of measles viruses in China, 1995–2003

Yan

Zhu

Rota

et al. 2007

Virol J

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This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%-100% and 93.3%-100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.

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Section: Resultsmentioning

confidence: 99%

Molecular epidemiology of measles viruses in China, 1995–2003

Yan

Zhu

Rota

et al. 2007

Virol J

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“…More than 109 000 cases were reported from China in 2007, representing 39 % of the global measles cases (Bian et al, 2006;Liffick et al, 2001;Xu et al, 1998;Yu et al, 2007;Zhang et al, 2008). H1 has also been observed in Korea and Japan (Na et al, 2003;Nakayama et al, 2003;Tomita, 2006;Zhou et al, 2003). In China, both H variants, P397 and L397, have been found since 1993 whereas in Korea and Japan, only the L397 variant has been detected in samples collected since 2000.…”

Section: Discussionmentioning

confidence: 99%

Measles viruses of genotype H1 evade recognition by vaccine-induced neutralizing antibodies targeting the linear haemagglutinin noose epitope

Finsterbusch

Wolbert

Deitemeier

et al. 2009

Journal of General Virology

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The linear haemagglutinin noose epitope (HNE; aa 379-410) is a protective B-cell epitope and considered to be highly conserved in both the vaccine and the wild-type measles virus (MeV) haemagglutinin (H) proteins. Vaccine virus-derived monoclonal antibodies (mAbs) BH6 and BH216, which target the HNE, neutralized MeVs of genotypes B3, C2, D4, D5, D6, D7 and D8, and the vaccine strain Edmonston Zagreb. In the case of genotype H1, only strain Berlin.DEU/ 44.01 was neutralized by these mAbs, whereas strains Shenyang.CHN/22.99 and Sofia.BGR/ 19.05 were not. The H gene sequences of these two strains showed an exchange of proline 397 (P397) to leucine (L397). Mutated H proteins, with P397 exchanged to L and vice versa, were compared with original H proteins by indirect fluorescence assay. H proteins exhibiting P397 but not those with L397 were recognized by BH6 and BH216. This indicates that L397 leads to the loss of the neutralizing HNE. In contrast, human sera obtained from vaccinees (n510) did not discriminate between genotype H1 variants P397 and L397. This concurs with the epidemiological observation that the live-attenuated vaccine protects against both H1 variants. Furthermore, we demonstrated that MeVs of genotype H1 also lack the neutralizing epitopes defined by the vaccine virus-induced mAbs BH15, BH125 and BH47. The loss of several neutralizing epitopes, as shown for H1 viruses currently circulating endemically in Asia, implies that epitope monitoring should be considered to be included in measles surveillance.

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“…51 The patient suffered from chronic GvHD at that time, and died of giant cell pneumonia. This case will be presented in a separate case report.…”

Section: Discussionmentioning

confidence: 99%

Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea

Lee

Choi

et al. 2004

Bone Marrow Transplant

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Summary:We reviewed 242 allogeneic hematopoietic stem cell transplantation (HSCT) recipients retrospectively over a 2-year period (January 1998-December 1999 in order to analyze the characteristics and assess the outcomes of infectious complications in patients after HSCT in Korea. Bacteria were the major pathogens before engraftment, and viral and fungal infections predominated during the post-engraftment period. Varicella zoster virus was the most common viral pathogen after engraftment. Cytomegalovirus disease occurred mainly in the late-recovery phase. The frequency of mold infection was higher than that of yeast. There was a relatively high incidence of tuberculosis (3.0%) and Pneumocystis carinii pneumonia (6.5%). One case of death by measles confirmed by autopsy was also noted. Overall, cumulative mortality was 43% (104/242), and 59.6% of these deaths (62/104) were infection-related. Allogeneic HSCT recipents from unrelated donors were prone to infectious complication and higher mortality than those from matched sibling (17/39 (43.6%) vs 45/203 (22.2%), respectively; Po0.01; odd ratio 2.5; 95% confidence interval 1.2-5.1). As infection was the main post-HSCT complication in our data, more attention should be given to the management of infections in HSCT recipients.

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Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000–2001 epidemic

Cited by 15 publications

References 32 publications

Molecular epidemiology of measles viruses in China, 1995–2003

Molecular epidemiology of measles viruses in China, 1995–2003

Measles viruses of genotype H1 evade recognition by vaccine-induced neutralizing antibodies targeting the linear haemagglutinin noose epitope

Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea

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