2024
DOI: 10.1128/spectrum.00508-24
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Genetic and chemical control of tuberculostearic acid production in Mycobacterium avium subspecies paratuberculosis

John P. Bannantine,
Shannon C. Duffy,
María A. Colombatti Olivieri
et al.

Abstract: Tuberculostearic acid (TBSA) is a fatty acid unique to mycobacteria and some corynebacteria and has been studied due to its diagnostic value, biofuel properties, and role in membrane dynamics. In this study, we demonstrate that TBSA production can be abrogated either by addition of pivalic acid to mycobacterial growth cultures or by a bfaA gene knockout encoding a flavin adenine dinucleotide (FAD)-binding oxidoreductase. Mycobacterium avium subspecies … Show more

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