Genetic and Drug-Induced Variation in Serum Albumin

Tárnoky, A. L.

doi:10.1016/s0065-2423(08)60087-6

Cited by 66 publications

(21 citation statements)

References 127 publications

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“…Many rare genetic variants of human serum albumin (alloalbumins) that differ in electrophoretic mobility from normal (common) albumin (albumin A) have been identified through population genetics surveys (1)(2)(3)(4)(5), in the course of clinical electrophoresis (5)(6)(7), or in blood donor surveys (8). As markers of mutation and migration, alloalbumins are of interest to geneticists, biochemists, and anthropologists, but they are not associated with disease.…”

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confidence: 99%

Point substitutions in Japanese alloalbumins.

Arai

Madison²,

Huss³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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We have completed the structural study of five rare types of inherited albumin variants (alloalbumins) discovered in the Biochemical Genetics Study of 15,581 unrelated children in Hiroshima and Nagasaki. We have also identified the structural chane inl five other alloalbumin specimens detected during clinical electrophoresis of sera from Japanese living near Tokyo. Each of the five albumin variants from Nagasaki and Hiroshima has a single amino acid substitution. AlU of these substitutions differ, and none has been reported in non-Japanese populations. No instances of proalbumin variants or of albumin B (the most frequent alloalbumins in Caucasians) were detected in the children in Hiroshima and Nagasaki. However, one instance of a variant proalbumin and two examples of albumin B occurred in Japanese from the vicinity of Tokyo. In addition a previously unreported point substitution was found in albumin Tochigi, which is present in two unrelated persons from Tochigi prefecture. Four of the point mutations in the Japanese alloalbumins are in close proximity in a short segment of the polypeptide chain (residues 354-382) in which three additional point substitutions have been reported in diverse populations. These results, combined with earlier data, suggest that point substitutions are grouped in certain segments of the albumin molecule.

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mentioning

confidence: 99%

Point substitutions in Japanese alloalbumins.

Arai

Madison²,

Huss³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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“…Isoelectric (2) alloalbuminaemic urine; (3) serum from the son ofalioalbumiMemic case;(4) alloalbuminaemic serum; (5) serum from a heteror,ygote albumin Kashmir carrier; (6) serum with normal albumin.…”

Section: Methodsmentioning

confidence: 99%

Classification of an Alloalbumin

Smith¹,

Ballantyne²,

Savva

et al. 1994

Ann Clin Biochem

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“…5) and abolishes the differences between serum and plasma albumin concentrations.P Significant overestimation of albumin occurs if plasma samples are used with the original BCP reagent but the modified BCP reagent permits the use of either serum or heparinised plasma.f" 50 An alternative method of overcoming the problem of turbidity is the use of bichromatic blanking which also corrects for turbidity due to proteins other than fibrinogen. 5 1 A recent report indicates that the Du Pont ACA II BCP procedure is subject to a heparin-induced negative bias at heparin concentrations likely to be encountered in commerical blood collection tubes. 52 The mechanism is not clear but may be related to the lower reagent pH.…”

Section: Bromocresol Purplementioning

confidence: 99%