Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: Insights from identical and fraternal twins

Amaral, Wellington Z.; Krueger, Robert F.; Ryff, Carol D.; Coe, Christopher L.

doi:10.1016/j.bbi.2015.05.010

Cited by 23 publications

(19 citation statements)

References 120 publications

(156 reference statements)

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“…Indeed, a large extended pedigree study indicated that the heritability of IL-6 was 0.25, which is somewhat closer to the heritability found in the present study 87 . Moreover, one of the twin studies that accounted for BMI in their models, as we did in the present study, showed that the heritability of IL=6 was 0.26 26 . TNF-α and IL-8 have featured less prominently in heritability studies of inflammatory traits.…”

Section: Discussionsupporting

confidence: 63%

“…The heritability of TNF-α, IL-6 and IL-8 have been published previously. Heritability estimates of IL-6 from twin studies range between 0.17 and 0.61, though the majority of studies indicate estimates closer to 0.61 25,26,[80][81][82][83] . The classical twin design has been criticized for giving upwardly biased heritability estimates { [84][85][86] .…”

Section: Discussionmentioning

confidence: 99%

“…TNF-α and IL-8 have featured less prominently in heritability studies of inflammatory traits. The heritability of TNF-α has been estimated between 0.26 and 0.53 25,26 . Only one study has, to the best our knowledge, investigated the heritability of IL-8 in humans prior to the present one and that estimated heritability of IL-8 to be 1.00 27 .…”

Section: Discussionmentioning

confidence: 99%

“…First, the etiologic origins of the relationship are unclear. Risk for suicide has been shown to be heritable 24 as have levels of TNF-α, IL-6 25,26 and IL-8 27 . However, no study has attempted to assess any potential overlap in the genetic factors that influence inflammation and suicide risk.…”

Section: Introductionmentioning

confidence: 99%

“…Third, increased adiposity is a well-established correlate of inflammation 41 , but studies on the relationship between inflammation and suicide have generally not examined the effect of adiposity on this relationship, or treated it as a nuisance covariate 9,11,39 . In particular, IL-6 production is thought to increase with adiposity, which is typically measured using its proxy body mass index (BMI), with up to a third of circulating IL-6 originating from adipose tissue [42][43][44] . Evidence for a link between suicide and BMI is mixed 45 .…”

Section: Introductionmentioning

confidence: 99%

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Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt

Knowles

Curran

Göring

et al. 2019

Brain, Behavior, and Immunity

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Background-Suicide is major public health concern. It is imperative to find robust biomarkers so that at-risk individuals can be identified in a timely and reliable manner. Previous work suggests mechanistic links between increased cytokines and risk for suicide, but questions remain regarding the etiology of this association, as well as the roles of sex and BMI. Methods-Analyses were conducted using a randomly-ascertained extended-pedigree sample of 1882 Mexican-American individuals (60% female, mean age=42.04, range=18-97). Genetic correlations were calculated using a variance components approach between the cytokines TNF-α, IL-6 and IL-8, and Lifetime Suicide Attempt and Current Suicidal Ideation. The potentially confounding effects of sex and BMI were considered. Results-159 individuals endorse a Lifetime Suicide Attempt. IL-8 and IL-6 shared significant genetic overlap with risk for suicide attempt (ρ g =0.49, p FDR =7.67x10 −3 ; ρ g =0.53, p FDR =0.01), but for IL-6 this was attenuated when BMI was included as a covariate (ρ g =0.37, se=0.23, p FDR =0.12). Suicide attempts were significantly more common in females (p FDR =0.

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Section: Discussionsupporting

confidence: 63%