Genetic and Environmental Determination of Human Sleep

Partinen, Markku; Kaprio, Jaakko; Koskenvuo, Markku; Putkonen, Pekka T.S.; Langinvainio, H

doi:10.1093/sleep/6.3.179

Cited by 224 publications

(158 citation statements)

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“…However, a number of studies assessed the relative influence of genetic and environmental factors on sleep duration among adults (de Castro, 2002;Heath et al, 1990;Hublin et al, 2013;Partinen et al, 1983;Watson et al, 2010). These studies showed that genetic factors accounted for 30-40% of individual differences in adult sleep duration, which is consistent with the findings of our study.…”

Section: Discussionmentioning

confidence: 99%

Genetic and Environmental Influences on Individual Differences in Sleep Duration During Adolescence

Velde

Boomsma

et al. 2013

Twin Res Hum Genet

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This study assessed to what extent genetic and environmental factors contributed to individual differences in adolescent sleep duration, and whether genetic and environmental contributions to sleep duration changed throughout adolescence. A twin-family design was used to gain insight into the genetic and environmental contributions to variation in sleep duration. The study sample consisted of 6,319 adolescent twins (44% males) and 1,359 non-twin siblings (44% males) in the age range of 12 to 20 years (mean age = 16.85, SD = 1.40). The participants self-reported usual sleep duration, which was categorized as less than 8 hours per night, 8-9 hours per night, and more than 9 hours per night. Results showed that the prevalence of shorter than optimum sleep duration, that is, less than 8 hours per night, was high, with the highest prevalence rates in later adolescence. The contribution of genetic and environmental factors to individual differences in sleep duration was dependent on age. Variation in sleep duration at the age of 12 years was accounted for by genetic (boys: 34%, girls: 36%), shared environmental (boys: 28%, girls: 45%), and non-shared environmental factors (boys: 38%, girls: 19%). At the age of 20 years, the role of genetic (boys: 47%, girls: 33%) and non-shared environmental factors (boys: 53%, girls: 67%) was more pronounced. It can be concluded from the results that individual differences in sleep duration were accounted for by genetic and non-shared environmental factors throughout adolescence, whereas shared environmental factors account for a substantial part of variation during early adolescence only.

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Section: Discussionmentioning

confidence: 99%

Genetic and Environmental Influences on Individual Differences in Sleep Duration During Adolescence

Velde

Boomsma

et al. 2013

Twin Res Hum Genet

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“…1), consistent with the influence of multiple, low-penetrance polymorphisms. Accordingly, several older studies reported for sleep duration moderate heritability estimates of 30-40 % [17][18][19].…”

Section: Sleep Durationmentioning

confidence: 99%

Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants

Landolt

2008

CPD

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Abstract:To better understand the neurobiology of sleep disorders, detailed understanding of circadian and homeostatic sleep-wake regulation in healthy volunteers is mandatory. Sleep physiology and the repercussions of experimentallyinduced sleep deprivation on sleep and waking electroencephalogram (EEG), vigilance and subjective state are highly variable, even in healthy individuals. Accumulating evidence suggests that many aspects of normal sleep-wake regulation are at least in part genetically controlled. Current heritability estimates of sleep phenotypes vary between approximately 20-40 % for habitual sleep duration, to over 90 % for the spectral characteristics of the EEG in nonREM sleep. The molecular mechanisms underlying the trait-like, inter-individual variation are virtually unknown, and the human genetics of normal sleep is only at the beginning of being explored. The first studies identified distinct polymorphisms in genes contributing to the endogenous circadian clock and neurochemical systems previously implicated in sleep-wake regulation, to modulate sleep architecture and sleep EEG, vulnerability to sleep loss, and subjective and objective effects of caffeine on sleep. These insights are reviewed here. They disclose molecular mechanisms contributing to normal sleep-wake regulation in humans, and have potentially important implications for the neurobiology of sleep-wake disorders and their pharmacological treatment.

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“…Sleep-wake traits, such as sleep duration and timing, are heritable 28 and regulated by numerous genes. 29 Animal and human studies also implicate genetic mechanisms in the etiology of insomnia.…”

Section: Genetics Of Sleep and Insomniamentioning

confidence: 99%

The Pathophysiology of Insomnia

Levenson

Kay

Buysse

2015

Chest

292

147

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Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with diffi culty falling asleep, frequent nighttime awakenings with diffi culty returning to sleep, and/or awakening earlier in the morning than desired. Although progress has been made in our understanding of the nature, etiology, and pathophysiology of insomnia, there is still no universally accepted model. Greater understanding of the pathophysiology of insomnia may provide important information regarding how, and under what conditions, the disorder develops and is maintained as well as potential targets for prevention and treatment.The aims of this report are (1) to summarize current knowledge on the pathophysiology of insomnia and (2) to present a model of the pathophysiology of insomnia that considers evidence from various domains of research. Working within several models of insomnia, evidence for the pathophysiology of the disorder is presented across levels of analysis, from genetic to molecular and cellular mechanisms, neural circuitry, physiologic mechanisms, sleep behavior, and self-report. We discuss the role of hyperarousal as an overarching theme that guides our conceptualization of insomnia. Finally, we propose a model of the pathophysiology of insomnia that integrates the various types of evidence presented.

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Genetic and Environmental Determination of Human Sleep

Cited by 224 publications

References 0 publications

Genetic and Environmental Influences on Individual Differences in Sleep Duration During Adolescence

Genetic and Environmental Influences on Individual Differences in Sleep Duration During Adolescence

Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants

The Pathophysiology of Insomnia

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