Genetic and environmental-genetic interaction rules for the myopia based on a family exposed to risk from a myopic environment

Li, Wenbo; Bai, Congxia; Liu, Hui

doi:10.1016/j.gene.2017.05.051

Cited by 32 publications

(31 citation statements)

References 28 publications

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“…We can use ACI to explore what extent genetic factors are involved in development of disease. Myopia, for example, myopia rate in children from two groups (parents with or without myopia), was 96.2% and 57.7, respectively [14]; ACI could be calculated as 63.0 for genetic role in myopia and belonged to a moderate effect (ACI > 45).…”

Section: Discussionmentioning

confidence: 99%

An Angle Compared Index with Hybrid of Changes in the Ratio and Amplitude for Quantitative Evaluation of Disease Risk, Biological Function, and Biomarker Efficacy

Jin

Liu

2019

BioMed Research International

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Objective. The purpose of this study was to describe variations of different cardinal frequency by using angle compared index (ACI). Methods. The basic principle of the analysis model is to comprehensively consider changes in both the ratio and absolute value as follows: ACI = arctan Pd⁎(1-Pc) / [Pc⁎(1-Pd)] + arctan (Pd - Pc) - 45, where Pd represent percentage of disease occurrence in disease group and Pc represent that in control group. The range of ACI was (0~90). Thus, ACIs from different cardinal frequency are comparable. Results. When biomarkers with similar ratio value, absolute value, or ACI but different positive frequencies were combined, although three indexes (ratio value, absolute value, or ACI) increased after two single biomarkers were combined, only ACI increased with similar amplitudes after two single biomarkers with the same ACI at different positive frequencies were combined. Conclusion. The ACI provides a better understanding power of biomarker and may be a relatively good index for evaluating the complex events represented by different cardinal frequency from new systems.

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Section: Discussionmentioning

confidence: 99%

An Angle Compared Index with Hybrid of Changes in the Ratio and Amplitude for Quantitative Evaluation of Disease Risk, Biological Function, and Biomarker Efficacy

Jin

Liu

2019

BioMed Research International

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“…Epidemiology studies suggest that the risk of myopia is doubled if children had one myopic parent, and 3-5 times if they had two [105], with a possible additive effect with subsequent generations [106]. In addition, monozygous twins have a 75-90% chance of having a similar refraction compared to 30% in dizygous twins [107][108][109].…”

Section: Inheritance and Genetics Of Myopiamentioning

confidence: 99%

Clinical Management and Control of Myopia in Children

Chia

Tay

2019

Updates on Myopia

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• Our understanding of the pathogenesis and etiology of myopia continues to evolve, and with it, various interventions that prevent or slow the progression of myopia. These include the use of bifocal spectacles, peripheral defocus spectacles and contact lenses, orthokeratology contact lenses, atropine and environmental interventions. • With various interventions available for myopia control, understanding the effectiveness, safety profile and cost of each intervention can aid the clinician in making collective decisions with patients and their families on the most appropriate intervention for each child. • An atropine-based protocol for the treatment of myopia developed based on evidence from studies collected thus far is discussed. This includes assessment of risk factors for myopia progression, factors to consider when starting atropine, monitoring response to atropine treatment and factors to consider before cessation of treatment. • It is important that there is continued assessment of the long-term effect and value of these treatments in preventing high myopia and its associated complications.

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“…For polygenic genetic diseases, susceptibility is affected by both genetic and environmental factors [5][6][7]. Heritability describes the degree to which the variation in a particular trait, such as disease susceptibility, is influenced by genetics and is generally expressed as a percentage (%).…”

Section: Introductionmentioning

confidence: 99%

Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance

Liu

2020

Computational and Mathematical Methods in Medicine

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Objective. To establish a model for estimating genetic risk using known and unknown family data. Methods. Four simulated datasets were generated for four paternal and maternal chromosomes. The simulated data for children were generated from the parental data according to the Mendelian law. The correlation coefficient between the children’s and paternal data was calculated, and 2R was defined as the heredity index for continuous data (HIC). The simulated continuous data were transformed into binary data according to the gene accumulation threshold (incidence); the incidences of children in the parental no-disease group and the disease onset group were obtained; the correlation coefficient (R) was calculated as expected R (Re). The ratio of observed R (Ro) and Re was defined as the Heredity index for binary data (HIB). Results. Different actual pedigree data (lunula and holding a hammer in the right or left hand) were successfully used to verify the accuracy of the model. The genetic risk was estimated according to the incidence in a population using a lookup table. Conclusion. Our findings indicate the reliability of the model based on the fact that the multigene effect constitutes the normal distribution. Thus, this model can be used for comprehensive analysis of the influence of genetic and nongenetic factors on the genetic phenotype and to estimate genetic risk using known and unknown family data.

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Genetic and environmental-genetic interaction rules for the myopia based on a family exposed to risk from a myopic environment

Cited by 32 publications

References 28 publications

An Angle Compared Index with Hybrid of Changes in the Ratio and Amplitude for Quantitative Evaluation of Disease Risk, Biological Function, and Biomarker Efficacy

An Angle Compared Index with Hybrid of Changes in the Ratio and Amplitude for Quantitative Evaluation of Disease Risk, Biological Function, and Biomarker Efficacy

Clinical Management and Control of Myopia in Children

Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance

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