Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians

Vinukonda, Govindaiah; Naushad, Shaik Mohammad; Jain, Jamal Md Nurul; Chintakindi, Krishna Prasad; Akella, Radha Rama Devi

doi:10.1016/j.cca.2009.04.015

Cited by 50 publications

(25 citation statements)

References 35 publications

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“…Recent genetic epidemiological observations revealed that many genetic variants may increase the risk of CAD, including, for example, polymorphisms in angiotensin-converting enzyme [17], apolipoprotein E [18], hepatic lipase [19], platelet glycoprotein IIb/IIIa [20] and transforming growth factor-b [21]. The risk of developing CAD is influenced by a number of factors, including [22][23][24]. Recently, growing evidence has shown that inflammation is a critical factor in all stages of the CAD process, including atherosclerosis, plaque destabilization, plaque rupture and post-ischemia damage to the myocardium [3,25].…”

Section: Discussionmentioning

confidence: 99%

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

Cho

et al. 2012

Inflamm. Res.

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Section: Discussionmentioning

confidence: 99%

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

Cho

et al. 2012

Inflamm. Res.

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“…It has also been observed that mild elevation or even moderate plasma Hcy is correlated with atherosclerosis [11]. Elevated plasma levels of Hcy injures endothelial cells [12,13], which increases oxidative modification of low-density lipoprotein-cholesterol (LDL-c) [14]. …”

Section: Introductionmentioning

confidence: 99%

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

Liu

et al. 2013

Cell Physiol Biochem

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Aims: To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease. Methods: We examined rs1801131, rs1801133, rs3736232, rs3736234, rs854563 and rs662 by TaqMan® SNP Genotyping Assays in 1075 subjects that underwent angiography. The angiographical characteristics of coronary atherosclerosis were defined by the Gensini Score system. Results: The T allele of rs1801133 was associated with coronary atherosclerosis severity with the OR = 1.49, 95% CI = 1.04-2.14. In MTHFR gene, haplotype T-A was a susceptibility haplotype to coronary atherosclerosis (OR = 1.27, 95% CI = 1.06-1.51) whereas haplotype C-A had a protective effect (OR = 0.83, 95% CI = 0.70-0.99). In addition, several synergistic effects between rs1801133 and conventional risk factors such as diabetes and smoking were found. Conclusions: Collectively, the results demonstrate that the T allele of rs1801133 conferred an increased risk for coronary atherosclerosis. The MTHFR C-A haplotype was a protective haplotype, while T-A haplotype was a susceptibility haplotype. The presence of the T allele of rs1801133 increases the odds of coronary atherosclerosis severity when associated with conventional risk factors.

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“…All the above events are likely to trigger the cascade of events leading to atherosclerosis and arterial thrombosis. Several SNPs were reported in genes regulating the one-carbon metabolic pathway such as glutamate carboxypeptidase II (GCPII C1561T), reduced folate carrier 1 (RFC G80A), serine hydroxyl methyl transferase 1 (cSHMT C1420T), thymidylate synthase (TYMS 5 0 -UTR) 28 bp tandem repeat, methylenetetrahydrofolatereductase (MTHFR C677T) and 5-methyltetrahydrofolate homocysteine S-methyl transferase (MTR A2756G) interfere with the uptake of folate, folate carrier, DNA synthesis, synthesis of methyltetrahydrofolate, remethylation of HCY and reductive methylation of cobalamin, whereas the presence of 2R allele of functional polymorphism in TYMS, i.e., 28 bp tandem repeat in 5 0 -UTR (transcription enhancer element) was found to affect transcription process compared to 3R allele and might modulate folate flux.Among the different polymorphisms of one-carbon metabolism, GCPII C1561T [15]; MTHFR C677T [16], and MTR A2756G are studied extensively in CAD cases [17]. MTHFR C677T was observed to be associated with independent risk for CAD in the subjects with low folate status [18].…”

Section: Introductionmentioning

confidence: 98%

Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus

et al. 2014

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The present work was aimed to study the association of one carbon genetic variants, hyperhomocysteinemia and oxidative stress markers, i.e., serum nitrite, plasma malondialdehyde (MDA) and glutathione (GSH) on intimal medial thickening (IMT) in patients with type 2 diabetes mellitus (T2D). A total number of 76 subjects from ACS Medical College and Hospital, Chennai, India were included in the study, i.e., Group I (n = 42) of T2D and Group II (n = 34) of age- and sex matched healthy controls. The glycated haemoglobin was measured by ion-exchange resin method; plasma homocysteine by Enzyme Linked Immunosorbant Assay method; serum nitrite (nitric oxide, NO), plasma MDA and GSH by spectrophotometric methods; the IMT by high frequency ultrasound. The polymorphisms of one carbon genetic variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism and amplified fragment length polymorphism methods. Results indicate that methyltetrahydrofolate homocysteine methyl transferase (MTR) A2756G allele was found to be protective in T2D and the other variants were not significantly associated with T2D. Glutamate carboxypeptidase II (GCP II) C1561T (r = 0.34; p = 0.05) and methylene tetrahydrofolate reductase (MTHFR) C677T (r = 0.35; 0.04) showed positive correlation with plasma homocysteine in T2D cases. In this study, MTR A2756G allele was found to be protective in T2D; GCP II C1561T and MTHFR C677T showed positive association with plasma homocysteine in T2D cases. Among all the genetic variants, MTR A2756G was found influence IMT. RFC 1 G80A and TYMS 5'-UTR 2R3R showed synergistically interact with MTR A2756G in influencing increase in IMT.

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Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians

Cited by 50 publications

References 35 publications

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease

OLR1,PON1andMTHFRGene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population

Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus

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