Genetic and Environmental Influences on Expression of Recurrent Headache as a Function of the Reporting Age in Twins

Svensson, Dan A.; Larsson, Bo; Waldenlind, Elisabet; Pedersen, Nancy L.

doi:10.1375/13690520260186461

Cited by 6 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed a trend for persistence of monthly HA if there were other HA sufferers in the family. A genetic risk exists for HA, especially for migraine, while other family factors such as coping methods and social functions of the family also contribute to the outcome of HA (50–52). In agreement with earlier follow-up studies, concomitant diseases (19) or HA in early life (19, 23, 53, 54) did not predict worsening or persistence of HA at puberty.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Headache Frequency in Adolescence

et al. 2006

View full text Add to dashboard Cite

Only a few studies have been published of the outcome of adolescent headache (HA). The aim of this study was to examine the predictors of the outcome of headache frequency. A population-based sample of 13-year-olds with or without HA (N=228) was followed to the age of 16 years. HA was classified on the basis of a face-to-face interview and clinical examination. The outcomes of monthly HA (>1/month) and non-frequent HA (0-1/month) were studied. Frequent use of analgesics, female gender and multiple non-headache pain predicted the persistence of monthly HA (>1/month). Significant predictors for worsening non-frequent HA (from 0 to 1/month to >1/month) were female gender, consistent migraine and high basic educational level of one parent. Adolescents frequently using analgesics constitute a risk group for a poor outcome of HA. Especially girls meeting this criterion should be considered a target group in the planning and implementing of preventive measures.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcome of Headache Frequency in Adolescence

et al. 2006

View full text Add to dashboard Cite

show abstract

“…A lifetime history of recurrent headache not associated with infection, fever or hangover was assessed by the algorithm used in our previous reports [5, 13, 19], which is in line with the International Headache Society criteria.…”

Section: Methodsmentioning

confidence: 99%

Latent class analysis of functional somatic symptoms in a population-based sample of twins

Kato

Sullivan

Pedersen

2010

Journal of Psychosomatic Research

Self Cite

View full text Add to dashboard Cite

Objective-This study aimed to investigate empirically how and in what way individuals with symptoms of functional somatic syndromes should be classified. We also aimed to look into genetic and environmental influences on the classification.Method-A total of 28531 twins aged 41-64 underwent screening interviews via a computerassisted data collection system from 1998 to 2002. Nine functional somatic symptoms (abnormal tiredness, general muscular pain, recurrent abdominal discomfort, back pain, gastroesophageal reflux, recurrent headache, recurrent urinary problem, dizziness, breathlessness at rest) were assessed using structured questions in a blinded manner. Latent class analysis was applied to the data. Structural equation modeling was further performed in order to estimate the relative importance of genetic and environmental influences on class probability.Results-Latent class analysis resulted in a 5-class solution. Individuals in the first class did not show any health problems. Those assigned to the second, third, and fourth classes tended to have abnormal tiredness, gastrointestinal problems, and pain-related symptoms, respectively. Individuals in the fifth class had multiple symptoms to a greater extent than the other classes. All the five classes showed modest genetic influences (7 -29% of the total variation) with gender differences except Class 3; however, the majority of influences on the class membership derived from unique environmental effects. Conclusion-The findings suggested the necessity of re-defining the existing classification criteria for functional somatic syndromes in terms of single (uncomplicated) or multiple

show abstract

“…recurrent headache. Studies have shown that familial environmental effects for recurrent headache are small whereas genetic effects are of importance [46]. Therefore we may assume an underlying genetic susceptibility for both headache and self-rated health.…”

Section: Familial and Genetic Factorsmentioning

confidence: 99%

A prospective study of health, life-style and psychosocial predictors of self-rated health

et al. 2006

View full text Add to dashboard Cite

The aim of this study was to investigate what psychosocial predictors, life-style factors and health behaviors in early adulthood are of importance for self-ratings of health after the age of 45. Like-sexed adult twins born 1926-1950 (n = 16,080) from the Swedish Twin Registry that participated in a questionnaire in 1973 and in a telephone interview conducted between 1998 and 2002 were included. Exposure data was collected in 1973 and information on self-rated health and covariates was collected at the second contact 25 years later. Logistic regression using Generalized Estimating Equations was used to evaluate the associations. Conditional logistic regression was used to control for familial and genetic effects in the sample. Pain, lack of exercise, smoking, obesity, unemployment, perceived stress and personality are associated with future poor self-rated health, after controlling for age, sex, illness, education and socio-economic status. Familial and genetic effects influence the associations between recurrent headache, exercise, obesity, and poor self-rated health. Overall, these findings provide support for long-term effects of health behavior and psychosocial risk factors on poor self-ratings of health, beyond the influence of obvious health consequences such as disorders or illnesses. Genetic and familial factors are of importance only for some of these associations.

show abstract

Genetic and Environmental Influences on Expression of Recurrent Headache as a Function of the Reporting Age in Twins

Cited by 6 publications

References 51 publications

Outcome of Headache Frequency in Adolescence

Outcome of Headache Frequency in Adolescence

Latent class analysis of functional somatic symptoms in a population-based sample of twins

A prospective study of health, life-style and psychosocial predictors of self-rated health

Contact Info

Product

Resources

About