Genetic and epigenetic aspects of celiac disease

Kocsis, Dorottya; Béres, Nóra; Veres, Gábor; Szabó, Dolóresz; Müller, Katalin Eszter; Arató, András; Juhász, Márk

doi:10.1556/oh.2014.29795

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Histones are crucial in suppressing or inducing gene expression. They are cross-linked by transglutaminase, and epigenetics is important in CD pathophysiology [73][74][75][76]. Being a substrate of mTG, histone cross-linking might reduce its availability.…”

Section: Enhancing Intestinal Permeabilitymentioning

confidence: 99%

Processed Food Additive Microbial Transglutaminase and Its Cross-Linked Gliadin Complexes Are Potential Public Health Concerns in Celiac Disease

Lerner¹,

Tenbusch²

2020

IJMS

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Microbial transglutaminase (mTG) is a survival factor for microbes, but yeasts, fungi, and plants also produce transglutaminase. mTG is a cross-linker that is heavily consumed as a protein glue in multiple processed food industries. According to the manufacturers' claims, microbial transglutaminase and its cross-linked products are safe, i.e., nonallergenic, nonimmunogenic, and nonpathogenic. The regulatory authorities declare it as "generally recognized as safe" for public users. However, scientific observations are accumulating concerning its undesirable effects on human health. Functionally, mTG imitates its family member, tissue transglutaminase, which is the autoantigen of celiac disease. Both these transglutaminases mediate cross-linked complexes, which are immunogenic in celiac patients. The enzyme enhances intestinal permeability, suppresses mechanical (mucus) and immunological (anti phagocytic) enteric protective barriers, stimulates luminal bacterial growth, and augments the uptake of gliadin peptide. mTG and gliadin molecules are cotranscytosed through the enterocytes and deposited subepithelially. Moreover, mucosal dendritic cell surface transglutaminase induces gliadin endocytosis, and the enzyme-treated wheat products are immunoreactive in CD patients. The present review summarizes and updates the potentially detrimental effects of mTG, aiming to stimulate scientific and regulatory debates on its safety, to protect the public from the enzyme's unwanted effects.

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Section: Enhancing Intestinal Permeabilitymentioning

confidence: 99%

Processed Food Additive Microbial Transglutaminase and Its Cross-Linked Gliadin Complexes Are Potential Public Health Concerns in Celiac Disease

Lerner¹,

Tenbusch²

2020

IJMS

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“…Many scientific studies have demonstrated that CD is a disease that involves various epigenetic mechanisms as well as it's genetic aspects. [2][3][4] Currently, a life-long gluten-free diet is an effective and available treatment option for patients with celiac disease. But, the widespread use of wheat-derived gluten in the food industry limits the effectiveness of life-long gluten diet [5].…”

Section: Introductionmentioning

confidence: 99%

The effect of a brain-targeted beverage on cognition in an older population

Yaşar¹

2020

Appl Med Res

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Background: celiac disease (cd) is a widespread disorder caused by an intolerance to gluten which is a protein found in many foods in genetically susceptible individuals. The disease is characterized by small-intestinal mucosal injury and nutrient malabsorption. Currently, in spite of a life-long gluten-free diet is the effective and available treatment option for patients with CD, the widespread use of wheat-derived gluten in the food industry limits the effectiveness of treatment. Therefore, it is needed to perform further studies on nondietary therapies which solve the causes of the disease. The Remember/Regeneration Therapy Method (RTM) is a novel holistic medicine approach that targets physiopathological changes in quadruplet body structures and includes various complementary methods such as acupuncture, ozone therapy, and phytotherapy, etc. in different combinations which are determined depending on the disease.

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“…Most of the prolamin proteins -present in wheat, rye and barley -may contain immunogenic epitopes causing adverse symptoms of CD through the induction of inflammatory responses of the intestinal mucosa which lead to villous atrophy and malabsorption [3,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…More than 90% of CD patients express the antigen-presenting molecules human leukocyte antigen (HLA)-DQ-2/2.2/8, however only in a part of HLA-DQ-2/2.2/8 positive individuals develops CD (40% of the population carries these haplotypes without any evidence of CD) [6]. Based on recent epidemiological studies, similarly to other immunemediated diseases (allergy or asthma) CD may appear at any age and its prevalence is continuously increasing [1].…”

Section: Introductionmentioning

confidence: 99%

Role of the Microbiome in Celiac Disease

Béres

Sziksz

Vannay

et al. 2016

IJCD

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Microbiome is the community of commensal, symbiotic and pathogenic microorganism that share our human body space. Intestinal microbiota has a defensive role in human health, it is implicated in metabolic and nutritional processes and plays an important role in the pathophysiology of several diseases. In recent years special attention has been paid to investigations targeting the changes of intestinal microbiome in various gastrointestinal disorders including inflammatory bowel disease, infectious colitis and celiac disease (CD). The aim of our present review is to summarize the role of the microbiome in CD and the changes of its composition in the intestine of patients suffering from CD.

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Genetic and epigenetic aspects of celiac disease

Cited by 5 publications

References 23 publications

Processed Food Additive Microbial Transglutaminase and Its Cross-Linked Gliadin Complexes Are Potential Public Health Concerns in Celiac Disease

Processed Food Additive Microbial Transglutaminase and Its Cross-Linked Gliadin Complexes Are Potential Public Health Concerns in Celiac Disease

The effect of a brain-targeted beverage on cognition in an older population

Role of the Microbiome in Celiac Disease

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