Genetic and epigenetic factors associated with depression: An updated overview

Alshaya, Dalal S.

doi:10.1016/j.sjbs.2022.103311

Cited by 34 publications

(16 citation statements)

References 59 publications

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“…In addition, Sirignano et al (2021) found FKBP5 as one out of two differentially methylated genes with a stringent statistical significance threshold associated with ECT. FKBP5 is a well-known gene involved in neuroendocrine signaling associated with MDD, supported by both genetic and epigenetic evidence ( Alshaya, 2022 ). Changes in FKBP5 gene expression in the blood are also associated with ECT treatment response ( Israel-Elgali et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Castro

Bicca

et al. 2023

Front. Hum. Neurosci.

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IntroductionElectroconvulsive therapy (ECT) is one of the most effective strategies for treating resistant major depression. Although the mechanism of action is not fully understood and studies are limited, epigenetics is a promising area for the development of biomarkers associated with ECT treatment response.AimWe reviewed studies available in the literature that explored the epigenetics of ECT in peripheral samples from patients with major depressive disorder (MDD).MethodsA systematic review was performed following The PRISMA guidelines. The search was performed in seven electronic databases: Scopus, Web of Science, Medline, PsycINFO, Embase, Cochrane, and Cinahl.ResultsNine studies were included. Seven assessed DNA methylation and three investigated microRNAs (miR). Overall, most studies were exploratory, with small sample sizes, and we found high heterogeneity between the study’s design, ECT protocols, molecular biology methods, and epigenetic findings. Investigated candidates with some evidence of association with ECT treatment response were BDNF, S100A10, RNF213M, TNKS, FKBP5, miR-126, miR-106a, and miR-24.ConclusionThe present findings seem to support previous preclinical research, suggesting that epigenetic mechanisms play an important role in the molecular mechanism underlying ECT effects.

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Section: Discussionmentioning

confidence: 99%

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Castro

Bicca

et al. 2023

Front. Hum. Neurosci.

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“…On the contrary, it is more believed that the clinical manifestations of depression are co-presented by the activation or silencing of many genes caused by environmental factors (gut dysbiosis, diet, infection, etc. ), the namely epigenetic mechanism ( Alshaya, 2022 ). The current research mainly involves three pathways: post-translational histone modifications, RNA interference, and DNA methylation ( Czarny et al, 2021 ).…”

Section: Potential Mechanism Of Gut Microbiota Involved In the Regula...mentioning

confidence: 99%

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

Han

Wang²,

Han³

et al. 2022

Front. Neurosci.

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The relationship between gut microbiota (GM) and mental health is one of the focuses of psychobiology research. In recent years, the microbial-gut-brain axis (MGBA) concept has gradually formed about this bidirectional communication between gut and brain. But how the GM is involved in regulating brain function and how they affect emotional disorders these mechanisms are tenuous and limited to animal research, and often controversial. Therefore, in this review, we attempt to summarize and categorize the latest advances in current research on the mechanisms of GM and depression to provide valid information for future diagnoses and therapy of mental disorders. Finally, we introduced some antidepressant regimens that can help restore gut dysbiosis, including classic antidepressants, Chinese materia medica (CMM), diet, and exogenous strains. These studies provide further insight into GM’s role and potential pathways in emotion-related diseases, which holds essential possible clinical outcomes for people with depression or related psychiatric disorders. Future research should focus on clarifying the causal role of GM in disease and developing microbial targets, applying these findings to the prevention and treatment of depression.

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“…Early-life adversity is a strong determinant of maladaptive personality in adults (de Carvalho et al, 2015;Perna, Vanni, Di Chiaro, Cavedini, & Caldirola, 2014;Rademaker, Vermetten, Geuze, Muilwijk, & Kleber, 2008;Schouw, Verkes, Schene & Schellekens, 2020). These trait effects depend on physiological alterations that include epigenetic modulation (Alshaya, 2022), HPA axis dysfunctionality (Lopez et al, 2021), and interruption of normal brain development (Marshall, Fox, & Group, 2004). Neither such environmental effects, related genes, nor their interaction can be thoroughly studied experimentally in humans.…”

Section: Genes Environment and Personalitymentioning

confidence: 99%

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

Lages

McNaughton²

2022

Personality Neuroscience

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The most fundamental emotional systems that show trait control are evolutionarily old and extensively conserved. Psychology in general has benefited from non-human neuroscience and from the analytical simplicity of behaviour in those with simpler nervous systems. It has been argued that integration between personality, psychopathology, and neuroscience is particularly promising if we are to understand the neurobiology of human experience. Here, we provide some general arguments for a non-human approach being at least as productive in relation to personality, psychopathology, and their interface. Some early personality theories were directly linked to psychopathology (e.g., Eysenck, Panksepp, and Cloninger). They shared a common interest in brain systems that naturally led to the use of non-human data; behavioural, neural, and pharmacological. In Eysenck’s case, this also led to the selective breeding, at the Maudsley Institute, of emotionally reactive and non-reactive strains of rat as models of trait neuroticism or trait emotionality. Dimensional personality research and categorical approaches to clinical disorder then drifted apart from each other, from neuropsychology, and from non-human data. Recently, the conceptualizations of both healthy personality and psychopathology have moved towards a common hierarchical trait perspective. Indeed, the proposed two sets of trait dimensions appear similar and may even be eventually the same. We provide, here, an introduction to this special issue of Personality Neuroscience, where the authors provide overviews of detailed areas where non-human data inform human personality and its psychopathology or provide explicit models for translation to human neuroscience. Once all the papers in the issue have appeared, we will also provide a concluding summary of them.

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Genetic and epigenetic factors associated with depression: An updated overview

Cited by 34 publications

References 59 publications

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

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