Genetic and immune-toxicologic studies on abnormal thyroid functions in hospital employees exposed to cytostatic drugs

Tompa, Anna; Jakab, Mátyás G.; Bíró, Anna; Major, Jenő

doi:10.1556/oh.2015.30064

Cited by 3 publications

(2 citation statements)

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“…The increased percentages of CAs, Th cells, and Th/Tc ratio among nurses exposed to cytostatics were even higher among persons with thyroid alterations than those without thyroid alterations, as previously described by us. [29] Without safety regulations, Hungarian nurses are more susceptible to anemia and thyroid dysfunctions than age-matched controls.…”

Section: Resultsmentioning

confidence: 99%

Genotoxic monitoring of nurses handling cytotoxic drugs

Tompa

Bíró

Jakab

2016

Asia-Pacific Journal of Oncology Nursing

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Objective:Several biomarkers may be used to detect harmful exposure and individual susceptibility to cancer. Monitoring of biomarkers related to exposure may have a significant effect on early detection of cell transformation, thereby aiding the primary prevention of various chronic and malignant diseases. Nurses who handle cytotoxic drugs are exposed to carcinogenic agents, which have the potential to interrupt the cell cycle and to induce chromosomal aberrations. The presence of high chromosomal aberrations indicates the need for intervention even when exposure to these carcinogens is low.Methods:Nationally representative samples of 552 nurses were investigated by a follow-up monitoring system. The measured biomarkers were clinical laboratory routine tests, completed with genotoxicological (chromosome aberrations [CAs] and sister chromatid exchanges [SCEs]) and immunotoxicological monitoring (ratio of lymphocyte subpopulations and lymphocyte activation markers) measured on peripheral blood lymphocytes. Results were compared to the data of 140 healthy, age-matched controls.Results:In nurses exposed to cytostatics, we observed a significantly increased frequency of CAs and SCEs compared with those in the controls. Cytostatic drug exposure also manifested itself in an increased frequency of helper T lymphocytes. Genotoxicological and immunotoxicological changes, as well as negative health effects (i.e., iron deficiency, anemia, and thyroid diseases), increased among cytostatic exposed subjects.Conclusions:These results raised concerns about the protection of nursing staff from chemical carcinogens in the working environment.

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Section: Resultsmentioning

confidence: 99%

Genotoxic monitoring of nurses handling cytotoxic drugs

Tompa

Bíró

Jakab

2016

Asia-Pacific Journal of Oncology Nursing

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“…One study was excluded because it reported on combined, instead of individual outcomes: adverse pregnancy outcomes combined, which included spontaneous abortion, stillbirth and congenital malformations . Finally, four studies reporting on the percentage of cells with CA of the same population of nurses in Hungary were excluded due to a lack of adjustment for significant effects of co-exposure to ionizing radiation on exposed subjects, which made it unclear whether the significant finding of higher percentage of cells with CA was due to occupational exposure to cancer chemotherapy agents or to the co-exposed individuals (Tompa et al 2016;Tompa et al 2006a;Tompa et al 2015;Tompa et al 2006b). 3 studies (e.g., liver biochemistry)…”

Section: Study Selection Diagrammentioning

confidence: 99%

NTP Monograph on the Systematic Review of Occupational Exposure to Cancer Chemotherapy Agents and Adverse Health Outcomes

2019

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The draft monograph, Systematic Review of Occupational Exposure to Cancer Chemotherapy Agents and Adverse Health Outcomes, was evaluated by the reviewers listed below. These reviewers served as independent scientists, not as representatives of any institution, company, or governmental agency. In this capacity, reviewers determined if the design and conditions of this NTP evaluation were appropriate and ensured that this NTP monograph presented the results and conclusions fully and clearly.

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„Rés a pajzson” – a pajzsmirigy modern képalkotó vizsgálata multidiszciplináris szemszögből

Palásti

Zombori

Kaiser

et al. 2021

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Összefoglaló. A pajzsmirigy az első szervek közé tartozik, melyek megjelenítésében, betegségeinek felfedezésében az ultrahang-diagnosztikának fontos szerepe van. A pajzsmirigybetegségek a lakosság jelentős részét érintik, és a technika fejlődésével egyre több pajzsmirigyeltérés, göb kerül felfedezésre. A pajzsmirigy rosszindulatú folyamatainak nincs egy bizonyos specifikus jele, viszont az ultrahangkép alapján meghatározhatók a malignitásra gyanús eltérések. Erre az elmúlt években több összefoglaló rendszer is született. Jelen összefoglaló tanulmányunknak az a célja, hogy bemutassuk a pajzsmirigy ultrahangdiagnosztikájának fejlődését; összehasonlítsuk az egyes leletezési rendszereket, úgymint TIRADS, EU-TIRADS, K-TIRADS, melyek célja a feltehetőleg rosszindulatú göbök kiszűrése, azonosítása a mindennapi rutinmunka során; vizsgáljuk a különböző rendszerek kapcsolatát a patológia által használt Bethesda-pontrendszerrel. Az ultrahangvizsgálat megfelelő értékelése, a pontrendszerek ismerete segíthet a pajzsmirigygöb differenciáldiagnózisában, a követési frekvencia meghatározásában, csökkentheti az aspirációs citológiák számát, ezzel támogatva a klinikai döntéshozatalt. Orv Hetil. 2021; 162(14): 530–541. Summary. The thyroid gland was one of the first organs, the ultrasound (US) examination of which has played an important role. The thyroid diseases affect a large part of the population, and with the development of imaging technology, more and more thyroid abnormalities, nodules and malignant lesions are being discovered. There are no specific signs of thyroid cancer, but the suspicious signs could be determined by US. In recent years, several systems have been developed. The aim of our review is to demonstrate the development of US diagnostics of the thyroid gland; to compare the different reporting systems, such as TIRADS, EU-TIRADS, K-TIRADS, which should help to identify the questionable lesions in the daily routine work. We examine the relationship between the different US systems and the Bethesda point score used by pathologists. The literature review shows that the US examination supports the clinical decisions, helps to select, who should have a fine-needle biopsy, and allows to determine the frequency of follow-up. The number of unnecessary fine-needle biopsies could be reduced, too. Our paper is part of a bigger research, the ethical license number is 23/2020, University of Szeged. Orv Hetil. 2021; 162(14): 530–541.

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Genetic and immune-toxicologic studies on abnormal thyroid functions in hospital employees exposed to cytostatic drugs

Cited by 3 publications

References 43 publications

Genotoxic monitoring of nurses handling cytotoxic drugs

Genotoxic monitoring of nurses handling cytotoxic drugs

NTP Monograph on the Systematic Review of Occupational Exposure to Cancer Chemotherapy Agents and Adverse Health Outcomes

„Rés a pajzson” – a pajzsmirigy modern képalkotó vizsgálata multidiszciplináris szemszögből

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