Genetic and immunological markers in pouchitis

Brett, PM; Yasuda, Noriko; Yiannakou, JY; Herbst, Friederike; Hj, Ellis; Vaughan, R; Rj, Nicholls; Ciclitira, P.J.

doi:10.1097/00042737-199610000-00003

Cited by 60 publications

(32 citation statements)

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“…Another interesting observation linking the presence of HLA Studies In CD HLA studies in CD have been more heterogeneous. this allele to severe UC was reported by Brett et al [72].…”

Section: Hla Gene Polymorphism In Ibd the Major Histocompatibility Cosupporting

confidence: 65%

“…The VNTR gene polymorphism in the IL-1RN gene as well as polymorphisms at positions [70], we could confirm that allele 2 was predominantly found in patients with extensive colitis. Other studies -511 and +3953 in the nearby IL-1B gene were shown to influence the level of production of their respective found that IL-1ra was increased in surgically treated IBD patients [71], and in patients with pouchitis [72], again protein. Recently it has been demonstrated that production of IL-1 by mononuclear cells of blood donors is showing that these markers were predominantly found in patients with a more severe form of disease.…”

Section: Hla Gene Polymorphism In Ibd the Major Histocompatibility Comentioning

confidence: 99%

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Genetics of Inflammatory Bowel Disease. The Candidate Gene Approach: Susceptibility versus Disease Heterogeneity

Peña

1998

Dig Dis

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Ulcerative colitis and Crohn’s disease are complex diseases of unknown etiology. Several genes are involved in the susceptibility. These genes are necessary to suffer from these diseases but not sufficient. Environmental factors trigger the inflammatory response. Evidence is accumulating that this response is abnormal in these patients. Therefore, the study of genes that are involved in the regulation of the inflammation may help to clarify the pathogenesis of the disease. The working hypothesis is that HLA and cytokine gene polymorphisms, of extreme importance in the regulation of inflammation, contribute to determining the heterogeneity of the disease and the prognosis. In this case, the candidate genes are those involved in the regulation of the immune response of the host. These studies may be of great importance in the tailoring of an appropriate treatment for particular subgroups of patients. A premise for the success of these studies is to use a solid classification, which should take into account the dynamic process and the natural evolution of the disease; to use a carefully selected and ethnically matched group of healthy controls, and to use the advanced molecular biological typing techniques. In the present article, this concept is explored by taking into account some of the recent findings obtained with the HLA and cytokine gene polymorphisms in inflammatory bowel diseases. The results support the concept that these gene polymorphisms are of greater importance in determining the severity of the disease than in determining the susceptibility to suffer from the disease. From this point of view, these studies are complementary and a necessary addition to studies using the whole genome approach in the effort to understand the genetics of these chronic multifactorial diseases.

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“…Another interesting observation linking the presence of HLA Studies In CD HLA studies in CD have been more heterogeneous. this allele to severe UC was reported by Brett et al [72].…”

Section: Hla Gene Polymorphism In Ibd the Major Histocompatibility Cosupporting

confidence: 65%

Section: Hla Gene Polymorphism In Ibd the Major Histocompatibility Comentioning

confidence: 99%

Genetics of Inflammatory Bowel Disease. The Candidate Gene Approach: Susceptibility versus Disease Heterogeneity

Peña

1998

Dig Dis

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“…The authors of one study have suggested that the presence of ANCAs may correlate with chronic pouchitis after ileal pouch-anal anastomosis (53 ), but this has not confirmed in other studies (51,54,55 ).…”

Section: As Tools For Disease Monitoringmentioning

confidence: 98%

Serologic Markers in Inflammatory Bowel Disease

Bossuyt¹

2006

Clinical Chemistry

184

136

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Inflammatory bowel disease (IBD) is an enduring disease involving mostly young people, with symptoms of bloody diarrhea and abdominal cramps. Several antibodies have been associated with IBD, the 2 most comprehensively studied being autoantibodies to neutrophils (atypical perinuclear anti-neutrophil cytoplasmic antibodies) and anti-Saccharomyces cerevisiae antibodies. This review focuses on the value of these antibodies for diagnosing IBD, differentiating Crohn disease from ulcerative colitis, indeterminate colitis, monitoring disease, defining clinical phenotypes, predicting response to therapy, and as subclinical markers. Pancreatic antibodies and newly identified anti-microbial antibodies (anti-outer membrane porin C, anti-I2, and anti-flagellin) are also reviewed.

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“…Proposed etiologies include fecal stasis, bacterial overgrowth, dysbiosis, genetic susceptibility, short-chain fatty acid deficiency, ischemic complications of surgery, bile-acid toxicity, immune alteration, a missed diagnosis of Crohn's disease (CD), or a recurrence of UC in the pouch. 1,6,7 Pouch bacteria appear central to the pathophysiology of the disease. The efficacy of antibiotics in ameliorating pouchitis underscores the role of mucosal or luminal bacteria in the development of pouchitis.…”

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confidence: 99%