Genetic and Lifestyle Predictors of 15‐Year Longitudinal Change in Episodic Memory

Josefsson, Maria; Luna, Xavier de; Pudas, Sara; Nilsson, Lars‐Göran; Nyberg, Lars

doi:10.1111/jgs.12000

Cited by 177 publications

(194 citation statements)

References 30 publications

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“…By contrast, older Met carriers and younger COMT genotype groups had identical and considerably weaker correlations between the two types of memory [50]. Most importantly, longitudinal data reveal less decline of executive functions over a 5-year interval [51], and less decline of episodic memory across 15 years [52], for older Met carriers than for Val homozygotes. Results from an fMRI study further suggest that older Val homozygotes are characterized by less efficient processing during a working memory task with low demands, as indicated by increased communication between distal brain regions, compared with Met homozygotes, potentially reflecting a compensatory response [53].…”

Section: Catechol-o-methyltransferase (Comt) Polymorphismmentioning

confidence: 90%

Aging-related magnification of genetic effects on cognitive and brain integrity

Papenberg

Lindenberger

Bäckman

2015

Trends in Cognitive Sciences

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Section: Catechol-o-methyltransferase (Comt) Polymorphismmentioning

confidence: 90%

Aging-related magnification of genetic effects on cognitive and brain integrity

Papenberg

Lindenberger

Bäckman

2015

Trends in Cognitive Sciences

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“…Furthermore, the COMT polymorphism affected the link between episodic and working memory in older, but not in younger, persons (Papenberg et al 2013), with Val homozygotes having lower performance outcomes. Most importantly, longitudinal data reveal less decline of executive function over a 5-year interval (de Frias et al 2005) and less episodic-memory decline across 15 years (Josefsson et al 2012) for COMT Met carriers than for Val homozygotes.…”

Section: Comt Polymorphismmentioning

confidence: 99%

Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

et al. 2015

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Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from agecomparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.

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“…Moreover, KIBRA-status was not able to predict whether individuals would decline or maintain episodic memory function over 15 years (Josefsson et al, 2012). Thus, the effect of the KIBRA SNP, rs17070145, on memory performance is still unclear, as indicated by a recent meta-analysis (Milnik et al, 2012) and review (Schwab et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure.However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145, rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.

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Genetic and Lifestyle Predictors of 15‐Year Longitudinal Change in Episodic Memory

Abstract: Quantitative, attrition-corrected assessment of longitudinal changes in memory can reveal substantial heterogeneity in aging trajectories, and genetic and lifestyle factors predict such heterogeneity.

Cited by 177 publications

References 30 publications

Aging-related magnification of genetic effects on cognitive and brain integrity

Aging-related magnification of genetic effects on cognitive and brain integrity

Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals

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